{"doi":"10.1016/j.bbrc.2007.02.107","title":"Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2007,"id":645619,"datarank":0.6610078870896381,"base_score":4.406719247264253,"endowment":4.406719247264253,"self_citation_contribution":0.6610078870896381,"citation_network_contribution":0.0,"self_endowment_contribution":0.6610078870896381,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":81,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1681187,"name":"Manabu Murakami","orcid":null,"position":1,"is_corresponding":false},{"id":1078755,"name":"Hiroyuki Watanabe","orcid":"0000-0001-8744-9799","position":2,"is_corresponding":false},{"id":151267,"name":"Hitoshi Hasegawa","orcid":null,"position":3,"is_corresponding":false},{"id":152564,"name":"Takayoshi Ohba","orcid":null,"position":4,"is_corresponding":false},{"id":1681190,"name":"Yoshiko Munehisa","orcid":null,"position":5,"is_corresponding":false},{"id":1681191,"name":"Kiyoshi Nobori","orcid":null,"position":6,"is_corresponding":false},{"id":1681192,"name":"Kyoichi Ono","orcid":null,"position":7,"is_corresponding":false},{"id":143988,"name":"Toshihiko Iijima","orcid":null,"position":8,"is_corresponding":false},{"id":1016194,"name":"Hiroshi Ito","orcid":"0000-0002-9857-8614","position":9,"is_corresponding":false},{"id":1681186,"name":"Yoichiro Takahashi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry","abstract":"Store-operated Ca(2+) entry (SOCE) is a physiologically important process that is triggered by intracellular Ca(2+) depletion. Recently, human Orai1 (the channel-forming subunit) and STIM1 (the calcium sensor) were identified as essential molecules for SOCE. Here, we report the cloning and functional analysis of three murine orthologs of Orai1, termed Orai1, 2, and 3. Among the genes identified, Orai1 contains a distinctive proline- and arginine-rich N-terminal cytoplasmic sequence. Co-expression of STIM1 with Orai1 produced a marked effect on SOCE, while co-expression with Orai2 or Orai3 had little effect. Expression of Orai1 without its N-terminal tail had a marginal effect on SOCE, while chimeric Orai2 containing the Orai1 N-terminus produced a marked increase in SOCE. In addition, a truncated version of Orai1 containing the N-terminus without the pore-forming transmembrane domain had a dominant negative effect on SOCE. These results reveal the essential role of Orai1 and its N-terminal sequence in SOCE.","is_dataset_classified":null,"base_score":4.406719247264253,"endowment":4.406719247264253,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17343823","pmcid":null,"openalex_id":"https://openalex.org/W1981953184","authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"16590656","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"17590700","title":null}],"total_grants":2,"fwci":2.5797,"citation_percentile":0.89844617,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":4},{"year":2014,"count":2},{"year":2015,"count":8},{"year":2016,"count":5},{"year":2017,"count":3},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":6},{"year":2022,"count":15},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X07003476?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X07003476?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2007.02.107","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17343823","host_type":"repository"}],"fields_of_study":["Ion Channels and Receptors","Phytochemicals and Antioxidant Activities","Neurobiology and Insect Physiology Research"],"mesh_terms":["Stromal Interaction Molecule 1","ORAI1 Protein","ORAI2 Protein","Amino Acid Sequence","Animals","Calcium","Cell Line","Cloning, Molecular","Humans","Male","Membrane Glycoproteins","Mice, Inbred C57BL","Molecular Sequence Data","Recombinant Fusion Proteins","Transfection","Blotting, Western","Calcium Channels","Sequence Homology, Amino Acid","Protein Isoforms","Reverse Transcriptase Polymerase Chain Reaction","Gene Expression Profiling","RNA Interference","Green Fluorescent Proteins","Mice"],"keywords":["ORAI1","STIM1","Cell biology","C-terminus","Cloning (programming)","Intracellular","Transmembrane domain","Chemistry","Biology","Molecular biology","Biochemistry","Endoplasmic reticulum","Gene","Amino acid"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T09:34:15.417684Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}