{"doi":"10.1016/j.bbrc.2006.03.242","title":"Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2006,"id":661403,"datarank":0.6698862177981877,"base_score":4.465908118654584,"endowment":4.465908118654584,"self_citation_contribution":0.6698862177981877,"citation_network_contribution":0.0,"self_endowment_contribution":0.6698862177981877,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":86,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1726633,"name":"Yousuke Kamimura","orcid":null,"position":1,"is_corresponding":false},{"id":1726635,"name":"Masaaki Hashiguchi","orcid":null,"position":2,"is_corresponding":false},{"id":1726637,"name":"Miyuki Azuma","orcid":null,"position":3,"is_corresponding":false},{"id":1726632,"name":"Noriko Otsuki","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells","abstract":"Co-signal receptors provide crucial activating or attenuating signals for T cells. The B and T lymphocyte attenuator (BTLA/CD272) is a third member of co-inhibitory receptors, which belongs to the CD28 immunoglobulin-superfamily. Using monoclonal antibodies (mAbs) against human BTLA, we show that BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. Polarized Th1 and Th2 cells contained both BTLA-positive and BTLA-negative populations, but the extended culture diminished BTLA expression. Cross-linking BTLA with an agonistic mAb inhibited T cell proliferation and the production of the cytokines IFN-gamma and IL-10 in response to anti-CD3 stimulation. BTLA-mediated inhibition of T cell activation occurred during both primary CD4+ T cell responses and secondary CD4+ and CD8+ T cell responses, suggesting that BTLA ligation sends a constitutive \"off\" signal to T cells and thus might play an important role in the maintenance of T cell tolerance.","is_dataset_classified":null,"base_score":4.465908118654584,"endowment":4.465908118654584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16643847","pmcid":null,"openalex_id":"https://openalex.org/W2038624388","authors":[],"funders":[{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"","title":null}],"total_grants":1,"fwci":1.5109,"citation_percentile":0.8224455,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":4},{"year":2015,"count":4},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":4},{"year":2019,"count":6},{"year":2020,"count":7},{"year":2021,"count":6},{"year":2022,"count":6},{"year":2023,"count":2},{"year":2024,"count":5},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X06008102?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X06008102?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2006.03.242","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16643847","host_type":"repository"}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Immunotherapy and Immune Responses"],"mesh_terms":["Antibodies, Monoclonal","Humans","Interferon-gamma","Lymphocyte Activation","Receptors, Immunologic","Interleukin-10","CD3 Complex","CD8-Positive T-Lymphocytes","Th1 Cells","Th2 Cells"],"keywords":["BTLA","CD28","T cell","T lymphocyte","CD8","CD3","Biology","Cytotoxic T cell","Lymphocyte","Antibody","Molecular biology","Immune system","Immunology","Cell biology","Biochemistry","In vitro"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T10:55:58.313181Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}