{"doi":"10.1016/j.bbrc.2005.11.075","title":"Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells","abstract":null,"journal":"Biochemical and Biophysical Research Communications","year":2006,"id":680806,"datarank":0.6190701577567639,"base_score":4.127134385045092,"endowment":4.127134385045092,"self_citation_contribution":0.6190701577567639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6190701577567639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1778748,"name":"Inkyoung Lee","orcid":null,"position":1,"is_corresponding":false},{"id":1561533,"name":"Chaehwa Park","orcid":null,"position":2,"is_corresponding":false},{"id":1750414,"name":"Won Ki Kang","orcid":null,"position":3,"is_corresponding":false},{"id":505234,"name":"Jeeyun Lee","orcid":"0000-0002-4911-6165","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells","abstract":"Lovastatin inhibits a 3-hydroxy 3-methylglutaryl coenzyme A reductase and prevents the synthesis of cholesterol precursors, such as farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), responsible for important cell signaling in cell proliferation and migration. Recently, the anti-cancer effect of lovastatin has been suggested in various tumor types. In this study, we showed that a low dose lovastatin induced senescence and G1 cell cycle arrest in human prostate cancer cells. Addition of GGPP or mevalonate, but not FPP, prevented the lovastatin-induced G1 phase cell cycle arrest and cell senescence. We found that constitutively active RhoA (caRhoA) reversed lovastatin-induced senescence in caRhoA-transfected PC-3 cells. Thus, we postulate that modulation of RhoA may be critical in lovastatin-induced senescence in PC-3 cells.","is_dataset_classified":null,"base_score":4.127134385045092,"endowment":4.127134385045092,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16316623","pmcid":null,"openalex_id":"https://openalex.org/W2023542270","authors":[],"funders":[],"total_grants":0,"fwci":1.0963,"citation_percentile":0.79497521,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":3},{"year":2014,"count":8},{"year":2015,"count":6},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006291X05025970?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006291X05025970?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbrc.2005.11.075","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16316623","host_type":"repository"}],"fields_of_study":["Cancer, Lipids, and Metabolism","Lipoproteins and Cardiovascular Health","interferon and immune responses"],"mesh_terms":["Antineoplastic Agents","Cell Cycle","Dose-Response Relationship, Drug","Humans","Lovastatin","Male","Prostatic Neoplasms","Gene Expression Regulation, Neoplastic","Cellular Senescence","rhoA GTP-Binding Protein","Cell Line, Tumor"],"keywords":["Lovastatin","RHOA","Farnesyl pyrophosphate","Senescence","Geranylgeranyl pyrophosphate","Prostate cancer","Cell cycle","Cell growth","Cancer cell","Cell","Chemistry","Cell cycle checkpoint","Biology","Cancer","Reductase","Cancer research","Cell biology","Endocrinology","Cholesterol","Biochemistry","Internal medicine","Signal transduction","Medicine","Enzyme","Biosynthesis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T16:08:43.943955Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}