{"doi":"10.1016/j.bbr.2024.115323","title":"Lower DTI-ALPS index in patients with major depressive disorder: Correlation with fatigue","abstract":null,"journal":"Behavioural Brain Research","year":2025,"id":690448,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":914320,"name":"Ping Jiang","orcid":"0000-0001-9953-6443","position":1,"is_corresponding":false},{"id":1803866,"name":"Peiwei Xu","orcid":null,"position":2,"is_corresponding":false},{"id":906958,"name":"Hai Lin","orcid":"0000-0003-3572-3236","position":3,"is_corresponding":false},{"id":940170,"name":"Jiaqi Xu","orcid":"0000-0002-4883-7358","position":4,"is_corresponding":false},{"id":1803867,"name":"Mingfeng Lai","orcid":null,"position":5,"is_corresponding":false},{"id":675819,"name":"Jianmin Yuan","orcid":"0000-0001-7223-2757","position":6,"is_corresponding":false},{"id":851604,"name":"Jiajun Xu","orcid":"0009-0003-6764-9461","position":7,"is_corresponding":false},{"id":1803865,"name":"Wenxin Bao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lower DTI-ALPS index in patients with major depressive disorder: Correlation with fatigue","abstract":"<h4>Background and purpose</h4>Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is an index that may provide insights into intracranial waste clearance processes. Glymphatic system dysfunction has been suggested to play a role in the development of major depressive disorder (MDD). Additionally, fatigue-a common precursor of MDD-is also closely connected to the waste clearance function of the central nervous system (CNS), further underscoring the significance of efficient waste removal in MDD. However, evidence linking altered DTI-ALPS index to MDD remains limited. This study aims to investigate the changes in the DTI-ALPS index in patients with MDD and explore the potential interplay between DTI-ALPS index alterations, fatigue, and the presence of MDD.<h4>Material and methods</h4>A total of 46 patients with MDD and 55 healthy controls (HC) were included in the study. All participants underwent diffusion tensor imaging using the same 3-T MRI (3-Tesla Magnetic Resonance Imaging) scanner. The DTI-ALPS index was assessed, and the Chalder Fatigue Scale (CFS) was used to evaluate fatigue levels in both groups, and the 17-item Hamilton Depression Rating Scale (HAMD-17) was used to evaluate the severity of depression in the patients. We compared the DTI-ALPS index and clinical characteristics between the MDD and HC group, and explored the relationship among the DTI-ALPS index, CFS scores, and the presence of MDD through mediation analysis.<h4>Results</h4>The DTI-ALPS index in the right hemisphere (DTI-ALPS-R) is significantly lower in patients with MDD (t = 2.41, P = 0.02). The MDD patients exhibited significantly higher scores on the CFS scales compared with HCs (t = 13.12, P <.001). Mediation analysis showed that the CFS score plays a significant mediating role between DTI-ALPS-R and the presence of MDD, acting as a full mediator (indirect effect β = -0.230, 95 % CI: [-0.388, -0.059]).<h4>Conclusion</h4>Our study found that patients with MDD have a reduced DTI-ALPS index. This reduction appears to contribute to the development of MDD by facilitating the accumulation of fatigue symptoms. These findings may provide a new perspective on the pathogenesis of MDD, suggest a potential new biomarker for MDD, and offer new insights for its treatment.","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39510329","pmcid":null,"openalex_id":"https://openalex.org/W4404059199","authors":[],"funders":[{"funder_name":"Sichuan University","grant_id":"2024HXFH044","title":null},{"funder_name":"Swiss Tumor Institute","grant_id":"2021ZD0202105","title":null},{"funder_name":"West China Hospital, Sichuan University","grant_id":"","title":null}],"total_grants":3,"fwci":5.5523,"citation_percentile":0.9699014,"influential_citations":0,"citation_trend":[{"year":2025,"count":14},{"year":2026,"count":16}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0166432824004790?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0166432824004790?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbr.2024.115323","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39510329","host_type":"repository"}],"fields_of_study":["Cerebrospinal fluid and hydrocephalus","Spinal Dysraphism and Malformations","Advanced Neuroimaging Techniques and Applications","Humans","Major Depressive Disorder","Female","Male","Diffusion Tensor Imaging","Adult","Fatigue","Middle Aged","Glymphatic System","Young Adult","Brain"],"mesh_terms":["Glymphatic System","Adult","Brain","Depressive Disorder, Major","Major Depressive Disorder","Fatigue","Female","Humans","Male","Middle Aged","Young Adult","Diffusion Tensor Imaging"],"keywords":["Major depressive disorder","Correlation","Psychology","Index (typography)","Medicine","Psychiatry","Clinical psychology","Cognition","Fatigue","Glymphatic Function","Dti-alps","Waste Clearance Function"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-24T12:37:16.850096Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}