{"doi":"10.1016/j.bbr.2021.113713","title":"Effects of synthetic cathinone naphyrone in the conditioned place preference test – Evidence of its addictive potential","abstract":null,"journal":"Behavioural Brain Research","year":2022,"id":685512,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1790998,"name":"Nikola Pinterová-Leca","orcid":null,"position":1,"is_corresponding":false},{"id":1790999,"name":"Klára Šíchová","orcid":null,"position":2,"is_corresponding":false},{"id":1791000,"name":"Kristýna Štefková-Mazochová","orcid":null,"position":3,"is_corresponding":false},{"id":1791001,"name":"Kateřina Syrová","orcid":null,"position":4,"is_corresponding":false},{"id":696791,"name":"Lucie Olejníková","orcid":"0000-0002-5313-3806","position":5,"is_corresponding":false},{"id":1791002,"name":"Markéta Končická","orcid":null,"position":6,"is_corresponding":false},{"id":1791003,"name":"Vladimír Mazoch","orcid":null,"position":7,"is_corresponding":false},{"id":1791004,"name":"Eva Lhotková","orcid":null,"position":8,"is_corresponding":false},{"id":1260015,"name":"Martin Kuchař","orcid":"0000-0002-7616-6352","position":9,"is_corresponding":false},{"id":1726357,"name":"Tomáš Páleníček","orcid":"0000-0002-3109-9539","position":10,"is_corresponding":false},{"id":1790997,"name":"Hynek Danda","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of synthetic cathinone naphyrone in the conditioned place preference test – Evidence of its addictive potential","abstract":"Naphyrone, also known as NRG-1, is a novel psychoactive substance (NPS), a cathinone with stimulatory properties available on the grey/illicit drug market for almost a decade. It is structurally related to infamously known powerful stimulants with the pyrovalerone structure, such as alpha-pyrrolidinovalerophenone (α-PVP) or methylenedioxypyrovalerone (MDPV) that are labeled as a cheap replacement for cocaine and other stimulants. Despite the known addictive potential of α-PVP and MDPV, there are no studies directly evaluating naphyrone's addictive potential e.g., in conditioned place preference (CPP) test or using self-administration. Therefore, our study was designed to evaluate the addictive potential in a CPP test in male Wistar rats and compare its effect to another powerful stimulant with a high addictive potential - methamphetamine. Naphyrone increased time spent in the drug-paired compartment with 5 and 20 mg/kg s.c. being significant and 10 mg/kg s.c. reaching the threshold (p = 0.07); the effect was comparable to that of methamphetamine 1.5 mg/kg s.c. The lowest dose, naphyrone 1 mg/kg s.c., had no effect on CPP. Interestingly, no dose response effect was detected. Based on these data, we are able to conclude that naphyrone has an addictive potential and may possess a significant risk to users.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34906607","pmcid":null,"openalex_id":"https://openalex.org/W4200296861","authors":[],"funders":[],"total_grants":0,"fwci":0.1413,"citation_percentile":0.42879353,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S016643282100601X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S016643282100601X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbr.2021.113713","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34906607","host_type":"repository"}],"fields_of_study":["Forensic Toxicology and Drug Analysis","Psychedelics and Drug Studies","Neurotransmitter Receptor Influence on Behavior","Alkaloids","Animals","Behavior, Animal","Central Nervous System Stimulants","Conditioning, Classical","Disease Models, Animal","Dose-Response Relationship, Drug","Male","Methamphetamine","Pentanones","Pyrrolidines","Rats","Rats, Wistar","Substance-Related Disorders"],"mesh_terms":["Alkaloids","Central Nervous System Stimulants","Animals","Behavior, Animal","Conditioning, Classical","Disease Models, Animal","Dose-Response Relationship, Drug","Male","Methamphetamine","Pentanones","Pyrrolidines","Rats, Wistar","Substance-Related Disorders","Rats"],"keywords":["Conditioned place preference","Cathinone","Methamphetamine","Addiction","Pharmacology","Stimulant","Psychology","Chemistry","Medicine","Amphetamine","Neuroscience","Dopamine","Cpp","Novel Psychoactive Substances","Naphyrone","Addictive Potential","Conditioned Place Preference Test"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T16:52:22.204098Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}