{"doi":"10.1016/j.bbr.2021.113140","title":"Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD","abstract":null,"journal":"Behavioural Brain Research","year":2021,"id":685009,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1789666,"name":"Derrick F. MacFabe","orcid":null,"position":1,"is_corresponding":false},{"id":1789667,"name":"Francis H. Boon","orcid":null,"position":2,"is_corresponding":false},{"id":1789668,"name":"Kelly A. Foley","orcid":null,"position":3,"is_corresponding":false},{"id":1789669,"name":"Donald P. Cain","orcid":null,"position":4,"is_corresponding":false},{"id":1687656,"name":"Klaus-Peter Ossenkopp","orcid":null,"position":5,"is_corresponding":false},{"id":1789665,"name":"Jennifer R. Mepham","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD","abstract":"Propionic acid (PPA) is produced by enteric gut bacteria and is a dietary short chain fatty acid. Intracerebroventricular (ICV) infusions of PPA in rodents have been shown to produce behavioural changes, including adverse effects on cognition, similar to those seen in autism spectrum disorders (ASD). Previous research has shown that repeated ICV infusions of PPA result in impaired spatial learning in a Morris water maze (MWM) as evidenced by increased search latencies, fewer direct and circle swims, and more time spent in the periphery of the maze than control rats. In the current study rats were first given non-spatial pretraining (NSP) in the water maze in order to familiarize the animals with the general requirements of the non-spatial aspects of the task before spatial training was begun. Then the effects of ICV infusions of PPA on acquisition of spatial learning were examined. PPA treated rats failed to show the positive effects of the non-spatial pretraining procedure, relative to controls, as evidenced by increased search latencies, longer distances travelled, fewer direct and circle swims, and more time spent in the periphery of the maze than PBS controls. Thus, PPA treatment blocked the effects of the pretraining procedure, likely by impairing sensorimotor components or memory of the pretraining.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33508348","pmcid":null,"openalex_id":"https://openalex.org/W3121554937","authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"","title":null}],"total_grants":2,"fwci":0.6325,"citation_percentile":0.60637181,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0166432821000279?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0166432821000279?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbr.2021.113140","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33508348","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.bbr.2021.113140","host_type":""}],"fields_of_study":["Autism Spectrum Disorder Research","Genetics and Neurodevelopmental Disorders","Memory and Neural Mechanisms","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Animals","Autism Spectrum Disorder","Behavior, Animal","Disease Models, Animal","Infusions, Intraventricular","Male","Maze Learning","Motor Activity","Propionates","Rats","Rats, Long-Evans"],"mesh_terms":["Autism Spectrum Disorder","Animals","Behavior, Animal","Disease Models, Animal","Male","Motor Activity","Propionates","Maze Learning","Rats, Long-Evans","Rats","Infusions, Intraventricular"],"keywords":["Spatial learning","Morris water navigation task","Water maze","Psychology","Spatial memory","T-maze","Spatial cognition","Radial arm maze","Neuroscience","Audiology","Developmental psychology","Cognition","Anesthesia","Working memory","Medicine","Hippocampus","Rat","Animal model","Morris Water Maze","Autism Spectrum Disorders","Short Chain Fatty Acid","Non-spatial Pretraining","Male","Behavior, Animal","Autism Spectrum Disorder","Motor Activity","Rats","Disease Models, Animal","Infusions, Intraventricular","Animals","Rats, Long-Evans","Propionates","Maze Learning"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T15:34:08.617814Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}