{"doi":"10.1016/j.bbmt.2020.04.015","title":"Long-Term Outcomes of Allogeneic Hematopoietic Cell Transplant with Fludarabine and Melphalan Conditioning and Tacrolimus/Sirolimus as Graft-versus-Host Disease Prophylaxis in Patients with Acute Lymphoblastic Leukemia","abstract":"Acute lymphoblastic leukemia (ALL) is associated with poor survival in older adults, and allogeneic hematopoietic cell transplant (HCT) with reduced-intensity conditioning (RIC) has been an increasingly used strategy in this population. At City of Hope we conducted a retrospective analysis of 72 patients who underwent allogeneic HCT with fludarabine and melphalan (FluMel) as the conditioning regimen between 2005 and 2018, from either a matched sibling or fully matched unrelated donor while in complete remission. Tacrolimus and sirolimus (T/S) were used as graft-versus-host disease (GVHD) prophylaxis. Overall survival and progression-free survival at 4 years post-HCT were 58% and 44%, respectively. The cumulative incidences of relapse/progression and nonrelapse mortality at 4 years were 34% and 22%, respectively. Patients with Philadelphia chromosome-positive (Ph+) ALL had a significantly lower cumulative incidence of relapse/progression (20% versus 48% for patients with Ph-negative status, P = .007). In conclusion, RIC HCT with FluMel conditioning and T/S GVHD prophylaxis was associated with favorable outcomes in patients with Ph+ ALL and should be considered as a viable consolidative therapy for adult patients with ALL.","journal":"Biology of Blood and Marrow Transplantation","year":2020,"id":73984,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9453,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":389253,"name":"Ni‐Chun Tsai","orcid":null,"position":1,"is_corresponding":false},{"id":319462,"name":"Sally Mokhtari","orcid":null,"position":2,"is_corresponding":false},{"id":318403,"name":"Monzr M. Al Malki","orcid":"0000-0001-8226-471X","position":3,"is_corresponding":false},{"id":235014,"name":"Haris Ali","orcid":"0000-0002-9728-7292","position":4,"is_corresponding":false},{"id":387637,"name":"Amandeep Salhotra","orcid":"0000-0002-9302-5041","position":5,"is_corresponding":false},{"id":387639,"name":"Karamjeet Sandhu","orcid":"0000-0001-8024-8484","position":6,"is_corresponding":false},{"id":387641,"name":"Samer K. Khaled","orcid":"0000-0003-3554-4625","position":7,"is_corresponding":false},{"id":387642,"name":"Eileen Smith","orcid":"0000-0003-2789-5046","position":8,"is_corresponding":false},{"id":389254,"name":"David S. Snyder","orcid":null,"position":9,"is_corresponding":false},{"id":108574,"name":"Guido Marcucci","orcid":"0000-0002-3983-5908","position":10,"is_corresponding":false},{"id":249979,"name":"Stephen J. Forman","orcid":"0000-0002-2803-4152","position":11,"is_corresponding":false},{"id":387643,"name":"Vinod Pullarkat","orcid":"0000-0001-9129-3424","position":12,"is_corresponding":false},{"id":89270,"name":"Anthony S. Stein","orcid":"0000-0002-1786-1398","position":13,"is_corresponding":false},{"id":233349,"name":"Ibrahim Aldoss","orcid":"0000-0001-9564-4498","position":14,"is_corresponding":false},{"id":284156,"name":"Ryotaro Nakamura","orcid":"0000-0002-9082-0680","position":15,"is_corresponding":false},{"id":387636,"name":"Matthew Mei","orcid":"0000-0002-1109-6955","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T21:45:52.171053Z","pmid":"32416253","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}