{"doi":"10.1016/j.bbmt.2011.11.013","title":"The Triterpenoid CDDO-Me Promotes Hematopoietic Progenitor Expansion and Myelopoiesis in Mice","abstract":null,"journal":"Biology of Blood and Marrow Transplantation","year":2012,"id":622345,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1607944,"name":"Salif Harouna","orcid":null,"position":1,"is_corresponding":false},{"id":1607946,"name":"Colin Meyer","orcid":null,"position":2,"is_corresponding":false},{"id":797629,"name":"Lisbeth A. Welniak","orcid":null,"position":3,"is_corresponding":false},{"id":259312,"name":"William J. Murphy","orcid":"0000-0002-2793-401X","position":4,"is_corresponding":false},{"id":1341666,"name":"Erik Ames","orcid":"0000-0002-4522-7319","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Triterpenoid CDDO-Me Promotes Hematopoietic Progenitor Expansion and Myelopoiesis in Mice","abstract":"The synthetic triterpenoid CDDO-Me has been shown to directly inhibit the growth of myeloid leukemias and lends itself to a wide array of therapeutic indications, including inflammatory conditions, because of its inhibition of NF-κB. We have previously demonstrated protection from acute graft-versus-host disease after CDDO-Me administration in an allogeneic bone marrow transplantation model. In the current study, we observed that CDDO-Me promoted myelopoiesis in both naive and transplanted mice. This effect was dose dependent, as high doses of CDDO-Me inhibited myeloid growth in vitro. All lineages (granulocyte macrophage colony-forming unit, BFU-E) were promoted by CDDO-Me. We then compared the effects with granulocyte colony-stimulating factor, a known inducer of myeloid expansion and mobilization from the bone marrow. Whereas both drugs induced terminal myeloid expansion in the spleen, peripheral blood, and bone marrow, granulocyte colony-stimulating factor only induced granulocyte macrophage colony-forming unit precursors in the spleen, while CDDO-Me increased these precursors in the spleen and bone marrow. After sublethal total-body irradiation, mice pretreated with CDDO-Me further displayed an accelerated recovery of myeloid progenitors and total nucleated cells in the spleen. A similar expansion of myeloid and myeloid progenitors was noted with CDDO-Me treatment after syngeneic bone marrow transplantation. Combined, these data suggest that CDDO-Me may be of use posttransplantation to accelerate myeloid recovery in addition to the prevention of graft-versus-host disease.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22100978","pmcid":"PMC3502000","openalex_id":"https://openalex.org/W1999611937","authors":[],"funders":[{"funder_name":"NIH","grant_id":"RO1 CA102282","title":null},{"funder_name":"NIH","grant_id":"PO1 CA055164","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA102282","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01 CA055164","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01CA102282-07","title":"Molecular targeting agents in GVHD/GVT: Role of cytokines and T cell subsets"}],"total_grants":5,"fwci":0.2283,"citation_percentile":0.52898432,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":2}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.bbmt.2011.11.013","host_type":"journal"},{"url":"https://doi.org/10.1016/j.bbmt.2011.11.013","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1083879111004836?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1083879111004836?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22100978","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3502000","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3502000","host_type":"repository"},{"url":"http://www.bbmt.org/article/S1083879111004836/pdf","host_type":"Unpaywall"},{"url":"http://dx.doi.org/10.1016/j.bbmt.2011.11.013","host_type":""},{"url":"https://dx.doi.org/10.1016/j.bbmt.2011.11.013","host_type":""}],"fields_of_study":["Immune Cell Function and Interaction","Cytokine Signaling Pathways and Interactions","Hematopoietic Stem Cell Transplantation","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Female","Hematopoietic Stem Cells","Mice","Mice, Inbred C57BL","Myelopoiesis","Oleanolic Acid"],"mesh_terms":["Animals","Female","Hematopoietic Stem Cells","Mice, Inbred C57BL","Oleanolic Acid","Hematopoietic Stem Cell Transplantation","Myelopoiesis","Mice"],"keywords":["Myelopoiesis","Medicine","Haematopoiesis","Progenitor cell","Progenitor","Cancer research","Immunology","Cell biology","Stem cell","Biology","Transplantation","Hematopoietic Stem Cell Transplantation","Hematology","Triterpenoids","Hematopoietic Stem Cells","CDDO-Me","Mice, Inbred C57BL","Mice","Animals","Female","Oleanolic Acid"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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