{"doi":"10.1016/j.bbih.2023.100631","title":"Glial suppression and post-traumatic stress disorder: A cross-sectional study of 1,520 world trade center responders","abstract":"Background: Chronically re-experiencing the memory of a traumatic event might cause a glial response. This study examined whether glial activation would be associated with PTSD in a study of responders present after the 9/11 World Trade Center attacks without comorbid cerebrovascular disease. Methods: Plasma was retrieved from 1,520 WTC responders and stored for a cross-sectional sample of responders of varying levels of exposure and PTSD. Plasma levels (pg/ml) of glial fibrillary acidic protein (GFAP) were assayed. Because stroke and other cerebrovascular diseases cause distributional shifts in GFAP levels, multivariable-adjusted finite mixture models analyzed GFAP distributions in responders with and without possible cerebrovascular disease. Results: Responders were aged 56.3 years and primarily male; 11.07% (n = 154) had chronic PTSD. Older age was associated with increased GFAP, whereas higher body mass was associated with decreased GFAP. Multivariable-adjusted finite mixture models revealed that severe re-experiencing trauma from 9/11 was associated with lower GFAP (B = -0.558, p = 0.003). Conclusion: This study presents evidence of reduced plasma GFAP levels among WTC responders with PTSD. Results suggest re-experiencing traumatic events might cause glial suppression.","journal":"Brain Behavior & Immunity - Health","year":2023,"id":336236,"datarank":0.6258353172092961,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.17647547617619744,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.17647547617619744,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":13,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9383,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":476521,"name":"Minos Kritikos","orcid":"0000-0003-2710-0717","position":1,"is_corresponding":false},{"id":264437,"name":"Pei Fen Kuan","orcid":"0000-0001-7861-916X","position":2,"is_corresponding":false},{"id":476524,"name":"Melissa A. Carr","orcid":"0000-0002-0870-6628","position":3,"is_corresponding":false},{"id":483623,"name":"Xiaohua Yang","orcid":"0000-0002-1508-7220","position":4,"is_corresponding":false},{"id":1066660,"name":"Yuan Yang","orcid":"0000-0003-2138-5811","position":5,"is_corresponding":false},{"id":343005,"name":"Roman Kotov","orcid":"0000-0001-9569-8381","position":6,"is_corresponding":false},{"id":264431,"name":"Evelyn J. Bromet","orcid":"0000-0002-2648-5793","position":7,"is_corresponding":false},{"id":366958,"name":"Sean Clouston","orcid":"0000-0002-6124-0329","position":8,"is_corresponding":false},{"id":264440,"name":"Benjamin J. Luft","orcid":"0000-0001-9008-7004","position":9,"is_corresponding":false},{"id":717112,"name":"Ginny Natale","orcid":"0000-0003-0837-4835","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:10:17.243221Z","pmid":"37251545","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}