{"doi":"10.1016/j.bbi.2023.06.027","title":"Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers – in cognitively unimpaired older adults","abstract":"Concentrations of pro-inflammatory cytokines -interleukin-6 (IL-6) and interleukin-8 (IL-8) - are increased with age and in Alzheimer's disease (AD). It is not clear whether concentrations of IL-6 and IL-8 in the central nervous system predict later brain and cognitive changes over time nor whether this relationship is mediated by core AD biomarkers. Here, 219 cognitively healthy older adults (62-91 years), with baseline cerebrospinal fluid (CSF) measures of IL-6 and IL-8 were followed over time - up to 9 years - with assessments that included cognitive function, structural magnetic resonance imaging, and CSF measurements of phosphorylated tau (p-tau) and amyloid-β (Aβ-42) concentrations (for a subsample). Higher baseline CSF IL-8 was associated with better memory performance over time in the context of lower levels of CSF p-tau and p-tau/Aβ-42 ratio. Higher CSF IL-6 was related to less CSF p-tau changes over time. The results are in line with the hypothesis suggesting that an up-regulation of IL-6 and IL-8 in the brain may play a neuroprotective role in cognitively healthy older adults with lower load of AD pathology.","journal":"Brain Behavior and Immunity","year":2023,"id":318718,"datarank":0.6307038929086449,"base_score":4.204692619390966,"endowment":4.204692619390966,"self_citation_contribution":0.6307038929086449,"citation_network_contribution":0.0,"self_endowment_contribution":0.6307038929086449,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":66,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259533,"name":"Leiv Otto Watne","orcid":"0000-0003-0441-6700","position":1,"is_corresponding":false},{"id":255766,"name":"Øystein Sørensen","orcid":"0000-0003-0724-3542","position":2,"is_corresponding":false},{"id":1026628,"name":"Carlijn Jamila Guichelaar","orcid":"0000-0002-0287-4049","position":3,"is_corresponding":false},{"id":1027395,"name":"Ane Victoria Idland","orcid":null,"position":4,"is_corresponding":false},{"id":1026629,"name":"Nathalie Bodd Halaas","orcid":"0000-0002-6048-6423","position":5,"is_corresponding":false},{"id":27600,"name":"Kaj Blennow","orcid":"0000-0002-1890-4193","position":6,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":7,"is_corresponding":false},{"id":255767,"name":"Kristine B. Walhovd","orcid":"0000-0003-1918-1123","position":8,"is_corresponding":false},{"id":255769,"name":"Anders M. Fjell","orcid":"0000-0003-2502-8774","position":9,"is_corresponding":false},{"id":255760,"name":"Didac Vidal‐Piñeiro","orcid":"0000-0001-9997-9156","position":10,"is_corresponding":false},{"id":1026627,"name":"Elettra Capogna","orcid":"0000-0002-8847-2461","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:07:06.454099Z","pmid":"37400002","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}