{"doi":"10.1016/j.bbcan.2021.188660","title":"Liquid biopsy for ovarian cancer using circulating tumor cells: Recent advances on the path to precision medicine","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","year":2022,"id":47082,"datarank":0.7788736745592313,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.3538916729507988,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.3538916729507988,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":15,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":217441,"name":"Shanshan Cheng","orcid":null,"position":1,"is_corresponding":false},{"id":1917,"name":"Nan Zhang","orcid":"0000-0002-0356-240X","position":2,"is_corresponding":false},{"id":217442,"name":"Yue Jin","orcid":null,"position":3,"is_corresponding":false},{"id":22277,"name":"Yu Wang","orcid":"0000-0003-4635-7059","position":4,"is_corresponding":false},{"id":217440,"name":"Jiani Yang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Liquid biopsy for ovarian cancer using circulating tumor cells: Recent advances on the path to precision medicine","abstract":"Ovarian cancer (OC) is the most lethal gynecologic malignance worldwide. Considering its metastasis nature, oncologists shift focus towards circulating tumor cells (CTCs), a progenitor that originates from primary tumor and undergoes morphologic/genetic alterations to enter bloodstream and invade nearby tissues. Mountains of evidence suggested that CTCs could provide deep insights into genomic, transcriptomic, and proteomic profiling of OC metastatic cascades. To pave the way for precision medicine, researchers exert great efforts to develop isolation/detection methodologies and construct CTCs-derived propagation platforms, including traditional cell cultures, patient-derived xenografts (PDXs), and organoids. From bench to bedside, CTCs provide minimally-invasive means to inform early diagnosis, predict prognosis, and guide treatment decisions. This review shined a spotlight on biology, detection technologies, and propagation platforms for CTCs. Of note, we also reviewed clinical applications of CTCs in liquid biopsy-based personalized cancer treatment and critically appraised limitations in routine clinical practice on the path to precision medicine.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34800546","pmcid":null,"openalex_id":"https://openalex.org/W3213176454","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81572560","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82072866","title":null}],"total_grants":2,"fwci":1.0536,"citation_percentile":0.80175758,"influential_citations":0,"citation_trend":[{"year":2022,"count":4},{"year":2023,"count":6},{"year":2024,"count":3},{"year":2025,"count":3}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1016/j.bbcan.2021.188660","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34800546","host_type":"repository"}],"fields_of_study":["Cancer Cells and Metastasis","Cancer Genomics and Diagnostics","Renal and related cancers","Medicine"],"mesh_terms":["Liquid Biopsy","Carcinoma, Ovarian Epithelial","Female","Humans","Neoplastic Cells, Circulating","Ovarian Neoplasms","Biomarkers, Tumor","Proteomics","Precision Medicine"],"keywords":["Circulating tumor cell","Liquid biopsy","Precision medicine","Ovarian cancer","Personalized medicine","Metastasis","Medicine","Bench to bedside","Organoid","Oncology","Cancer research","Bioinformatics","Computational biology","Internal medicine","Cancer","Biology","Pathology","Medical physics","Neuroscience","Circulating Tumor Cells"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-16T04:18:35.875776Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}