{"doi":"10.1016/j.bbcan.2004.01.001","title":"Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","year":2004,"id":590392,"datarank":10.840803491510865,"base_score":5.37989735354046,"endowment":5.37989735354046,"self_citation_contribution":0.8069846030310691,"citation_network_contribution":10.033818888479797,"self_endowment_contribution":0.8069846030310691,"citer_contribution":10.033818888479797,"corpus_percentile":null,"corpus_rank":null,"citation_count":216,"citer_count":200,"citers_with_citation_signal":165,"citers_with_endowment":165,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":7895,"name":"Alan Ashworth","orcid":"0000-0003-1446-7878","position":1,"is_corresponding":false},{"id":96365,"name":"Manuela Santarosa","orcid":"0000-0001-7682-2578","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way","abstract":"Classical tumour suppressor genes are thought to require mutation or loss of both alleles to facilitate tumour progression. However, it has become clear over the last few years that for some genes, haploinsufficiency, which is loss of only one allele, may contribute to carcinogenesis. These effects can either be directly attributable to the reduction in gene dosage or may act in concert with other oncogenic or haploinsufficient events. Here we describe the genes that undergo this phenomenon and discuss possible mechanisms that allow haploinsufficiency to display a phenotype and facilitate the pathogenesis of cancer.","is_dataset_classified":null,"base_score":5.37989735354046,"endowment":5.37989735354046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15172699","pmcid":null,"openalex_id":"https://openalex.org/W2057496292","authors":[],"funders":[{"funder_name":"Breast Cancer Now","grant_id":"BREAST CANCER NOW RESEARCH CENTRE","title":null}],"total_grants":1,"fwci":10.3815,"citation_percentile":0.98928105,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":11},{"year":2014,"count":15},{"year":2015,"count":4},{"year":2016,"count":6},{"year":2017,"count":3},{"year":2018,"count":8},{"year":2019,"count":6},{"year":2020,"count":3},{"year":2021,"count":5},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304419X04000022?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304419X04000022?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbcan.2004.01.001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15172699","host_type":"repository"}],"fields_of_study":["Cancer-related Molecular Pathways","Ubiquitin and proteasome pathways","Microtubule and mitosis dynamics","Alleles","Breast Neoplasms","Colorectal Neoplasms","Disease Progression","Female","Genes, Tumor Suppressor","Humans","Leukemia","Loss of Heterozygosity","Male","Models, Biological","Models, Genetic","Mutation","Neoplasms","Phenotype","Prostatic Neoplasms","Time Factors"],"mesh_terms":["Alleles","Breast Neoplasms","Female","Humans","Leukemia","Male","Models, Biological","Models, Genetic","Mutation","Neoplasms","Phenotype","Prostatic Neoplasms","Time Factors","Colorectal Neoplasms","Genes, Tumor Suppressor","Disease Progression","Loss of Heterozygosity"],"keywords":["Haploinsufficiency","Suppressor","Allele","Phenotype","Carcinogenesis","Genetics","Gene","Biology","Mutation","Tumor suppressor gene","Cancer research"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T19:49:26.339281Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}