{"doi":"10.1016/j.bbamem.2019.01.013","title":"Minimal nanodisc without exogenous lipids for stabilizing membrane proteins in detergent-free buffer","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Biomembranes","year":2019,"id":679662,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":834231,"name":"Marie Glavier","orcid":"0000-0002-7100-7045","position":1,"is_corresponding":false},{"id":906221,"name":"Guy Schoehn","orcid":"0000-0002-1459-3201","position":2,"is_corresponding":false},{"id":1775814,"name":"Gilles Phan","orcid":null,"position":3,"is_corresponding":false},{"id":1775815,"name":"Jean-Christophe Taveau","orcid":null,"position":4,"is_corresponding":false},{"id":1775816,"name":"Marion Decossas","orcid":null,"position":5,"is_corresponding":false},{"id":686496,"name":"Sophie Lecomte","orcid":"0000-0001-8310-4849","position":6,"is_corresponding":false},{"id":991722,"name":"Sébastien Mongrand","orcid":"0000-0002-9198-015X","position":7,"is_corresponding":false},{"id":1775818,"name":"Cyril Garnier","orcid":null,"position":8,"is_corresponding":false},{"id":1775820,"name":"Isabelle Broutin","orcid":null,"position":9,"is_corresponding":false},{"id":1775822,"name":"Laetitia Daury","orcid":null,"position":10,"is_corresponding":false},{"id":1775823,"name":"Olivier Lambert","orcid":null,"position":11,"is_corresponding":false},{"id":1775812,"name":"Dimitri Salvador","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Minimal nanodisc without exogenous lipids for stabilizing membrane proteins in detergent-free buffer","abstract":"Membrane protein stabilization after detergent solubilization presents drawbacks for structural and biophysical studies, in particular that of a reduced stability in detergent micelles. Therefore, alternative methods are required for efficient stabilization. Lipid nanodisc made with the membrane scaffold protein MSP is a valuable system but requires a fine optimization of the lipid to protein ratio. We present here the use of the scaffold protein MSP without added lipids as a minimal system to stabilize membrane proteins. We show that this method is applicable to α-helical and β-strands transmembrane proteins. This method allowed cryo-electron microscopy structural study of the bacterial transporter MexB. A protein quantification indicates that MexB is stabilized by two MSP proteins. This simplified and efficient method proposes a new advance in harnessing the MSP potential to stabilize membrane proteins.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30707889","pmcid":null,"openalex_id":"https://openalex.org/W2913631784","authors":[],"funders":[{"funder_name":"ANR","grant_id":"ANR-17CE11-0028","title":null},{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-11-INBS-0010","title":null},{"funder_name":"Bordeaux INP","grant_id":"","title":null},{"funder_name":"Conseil Régional Aquitaine","grant_id":"","title":null}],"total_grants":4,"fwci":0.3217,"citation_percentile":0.64080416,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":1},{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/am/pii/S0005273619300240","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/am/pii/S0005273619300240","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0005273619300240?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0005273619300240?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbamem.2019.01.013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30707889","host_type":"repository"},{"url":"https://hal.science/hal-02070464","host_type":"repository"},{"url":"https://hal.archives-ouvertes.fr/hal-02350080","host_type":"repository"},{"url":"https://hal.archives-ouvertes.fr/hal-03181433","host_type":"repository"},{"url":"https://oskar-bordeaux.fr/handle/20.500.12278/109291","host_type":"repository"},{"url":"https://oskar-bordeaux.fr/handle/20.500.12278/3796","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.bbamem.2019.01.013","host_type":""},{"url":"https://hal.science/hal-02070464v1","host_type":""},{"url":"https://hal.science/hal-02070464v1/document","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.bbamem.2019.01.013","host_type":""}],"fields_of_study":["Bacterial Genetics and Biotechnology","Lipid Membrane Structure and Behavior","RNA and protein synthesis mechanisms","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Bacterial Outer Membrane Proteins","Buffers","Membrane Lipids","Cryoelectron Microscopy","Nanostructures"],"keywords":["Nanodisc","Membrane protein","Transmembrane protein","Integral membrane protein","Chemistry","Membrane","Biophysics","Micelle","Biochemistry","Biology","Receptor","Lipids","Cryoem","570","[CHIM.MATE] Chemical Sciences/Material chemistry","572","Molecular Biology/Structural Biology [q-bio.BM]","[SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]","Cryoelectron Microscopy","[CHIM.MATE]Chemical Sciences/Material chemistry","Buffers","[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry","Nanostructures","Membrane Lipids","Bacterial Outer Membrane Proteins"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T13:34:28.479520Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}