{"doi":"10.1016/j.bbamem.2016.08.010","title":"Important roles for membrane lipids in haloarchaeal bioenergetics","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Biomembranes","year":2016,"id":689029,"datarank":0.6414999178524083,"base_score":4.276666119016055,"endowment":4.276666119016055,"self_citation_contribution":0.6414999178524083,"citation_network_contribution":0.0,"self_endowment_contribution":0.6414999178524083,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":698209,"name":"Marcos Y. Yoshinaga","orcid":"0000-0002-5533-5348","position":1,"is_corresponding":false},{"id":131845,"name":"Raymond C. Valentine","orcid":null,"position":2,"is_corresponding":false},{"id":1687817,"name":"Lars Wörmer","orcid":"0000-0002-3673-3826","position":3,"is_corresponding":false},{"id":861731,"name":"David L. Valentine","orcid":"0000-0001-5914-9107","position":4,"is_corresponding":false},{"id":131843,"name":"Matthias Y. Kellermann","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Important roles for membrane lipids in haloarchaeal bioenergetics","abstract":"Recent advances in lipidomic analysis in combination with various physiological experiments set the stage for deciphering the structure-function of haloarchaeal membrane lipids. Here we focused primarily on changes in lipid composition of Haloferax volcanii, but also performed a comparative analysis with four other haloarchaeal species (Halobacterium salinarum, Halorubrum lacusprofundi, Halorubrum sodomense and Haloplanus natans) all representing distinctive cell morphologies and behaviors (i.e., rod shape vs. pleomorphic behavior). Common to all five haloarchaea, our data reveal an extraordinary high level of menaquinone, reaching up to 72% of the total lipids. This ubiquity suggests that menaquinones may function beyond their ordinary role as electron and proton transporter, acting simultaneously as ion permeability barriers and as powerful shield against oxidative stress. In addition, we aimed at understanding the role of cations interacting with the characteristic negatively charged surface of haloarchaeal membranes. We propose for instance that by bridging the negative charges of adjacent anionic phospholipids, Mg<sup>2+</sup> acts as surrogate for cardiolipin, a molecule that is known to control curvature stress of membranes. This study further provides a bioenergetic perspective as to how haloarchaea evolved following oxygenation of Earth's atmosphere. The success of the aerobic lifestyle of haloarchaea includes multiple membrane-based strategies that successfully balance the need for a robust bilayer structure with the need for high rates of electron transport - collectively representing the molecular basis to inhabit hypersaline water bodies around the planet.","is_dataset_classified":null,"base_score":4.276666119016055,"endowment":4.276666119016055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27565574","pmcid":null,"openalex_id":"https://openalex.org/W2513624307","authors":[],"funders":[{"funder_name":"National Science Foundation grant","grant_id":"OCE-1333162","title":null},{"funder_name":"National Science Foundation grant","grant_id":"EAR-0950600","title":null},{"funder_name":"National Science Foundation grant","grant_id":"OCE-1046144","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"HI 616-14-1","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":5,"fwci":2.0778,"citation_percentile":0.87132727,"influential_citations":0,"citation_trend":[{"year":2017,"count":5},{"year":2018,"count":1},{"year":2019,"count":7},{"year":2020,"count":4},{"year":2021,"count":11},{"year":2022,"count":8},{"year":2023,"count":12},{"year":2024,"count":11},{"year":2025,"count":5},{"year":2026,"count":7}],"oa_status":"closed","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0005273616302814?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0005273616302814?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbamem.2016.08.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27565574","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.bbamem.2016.08.010","host_type":""}],"fields_of_study":["Coenzyme Q10 studies and effects","Mitochondrial Function and Pathology","Diet and metabolism studies","0301 basic medicine","0303 health sciences","03 medical and health sciences","Adaptation, Physiological","Aerobiosis","Antioxidants","Biological Evolution","Cations, Divalent","Cell Membrane","Electron Transport","Energy Metabolism","Halobacterium salinarum","Haloferax volcanii","Halorubrum","Magnesium","Membrane Lipids","Oxygen","Phospholipids","Salinity","Seawater","Static Electricity","Vitamin K 2"],"mesh_terms":["Adaptation, Physiological","Aerobiosis","Antioxidants","Cations, Divalent","Cell Membrane","Electron Transport","Energy Metabolism","Biological Evolution","Magnesium","Membrane Lipids","Oxygen","Phospholipids","Seawater","Halobacterium salinarum","Haloferax volcanii","Vitamin K 2","Salinity","Halorubrum","Static Electricity"],"keywords":["Bioenergetics","Chemistry","Membrane","Biophysics","Biology","Biochemistry","HPLC-MS","Membrane Adaptation","Lipidomic-bioenergetic Analysis","Membrane Forming Lipids, Non-membrane Forming Lipids","Halobacterium salinarum","Salinity","Cations, Divalent","Cell Membrane","Static Electricity","Vitamin K 2","Adaptation, Physiological","Biological Evolution","Aerobiosis","Antioxidants","Electron Transport","Oxygen","Membrane Lipids","Magnesium","Seawater","Halorubrum","Energy Metabolism","Haloferax volcanii","Phospholipids"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T21:37:29.605690Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}