{"doi":"10.1016/j.bbalip.2019.06.016","title":"Faraway, so close! Functions of Endoplasmic reticulum–Endosome contacts","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","year":2020,"id":661457,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1726773,"name":"Catherine Tomasetto","orcid":null,"position":1,"is_corresponding":false},{"id":483210,"name":"Fabien Alpy","orcid":"0000-0002-0526-0720","position":2,"is_corresponding":false},{"id":1726771,"name":"Thomas Di Mattia","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Faraway, so close! Functions of Endoplasmic reticulum–Endosome contacts","abstract":"Eukaryotic cells are partitioned into functionally distinct organelles. Long considered as independent units in the cytosol, organelles are actually in constant and direct interaction with each other, mostly through the establishment of physical connections named membrane contact sites. Membrane contact sites constitute specific active regions involved in organelle dynamics, inter-organelle exchanges and communications. The endoplasmic reticulum (ER), which spreads throughout the cytosol, forms an extensive network that has many connections with the other organelles of the cell. Ample connections between the ER and endocytic organelles are observed in many cell types, highlighting their prominent physiological roles. Even though morphologically similar - a contact is a contact -, the identity of ER-Endosome contacts is defined by their specific molecular composition, which in turn determines the function of the contact. Here, we review the molecular mechanisms of ER-Endosome contact site formation and their associated cellular functions. This article is part of a Special Issue entitled Endoplasmic reticulum platforms for lipid dynamics edited by Shamshad Cockcroft and Christopher Stefan.","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31252175","pmcid":null,"openalex_id":"https://openalex.org/W2954432624","authors":[],"funders":[{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-10-IDEX-0002","title":null},{"funder_name":"Institut National Du Cancer","grant_id":"","title":null},{"funder_name":"Ligue Contre le Cancer","grant_id":"","title":null},{"funder_name":"Université de Strasbourg","grant_id":"","title":null},{"funder_name":"Centre National de la Recherche Scientifique","grant_id":"","title":null},{"funder_name":"Institut National de la Santé et de la Recherche Médicale","grant_id":"","title":null},{"funder_name":"Fondation pour la Recherche Médicale","grant_id":"","title":null}],"total_grants":7,"fwci":1.9336,"citation_percentile":0.84398989,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":7},{"year":2021,"count":3},{"year":2022,"count":8},{"year":2023,"count":2},{"year":2024,"count":7},{"year":2025,"count":11},{"year":2026,"count":3}],"oa_status":"bronze","license":"Elsevier TDM","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/am/pii/S1388198119301192?via%3Dihub","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/am/pii/S1388198119301192?via%3Dihub","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1388198119301192?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1388198119301192?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbalip.2019.06.016","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31252175","host_type":"repository"},{"url":"https://hal.science/hal-03409560","host_type":"repository"},{"url":"https://univoak.eu/islandora/object/islandora%3A152407","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.bbalip.2019.06.016","host_type":""},{"url":"https://hal.science/hal-03409560v1/document","host_type":""},{"url":"https://hal.science/hal-03409560v1","host_type":""}],"fields_of_study":["Cellular transport and secretion","Calcium signaling and nucleotide metabolism","Lipid Membrane Structure and Behavior","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Biological Transport","Cell Membrane","Endoplasmic Reticulum","Humans","Endosomes","Calcium Signaling","Lipid Metabolism"],"keywords":["Endoplasmic reticulum","Organelle","Endosome","Membrane contact site","Endocytic cycle","Cell biology","Cytosol","Biology","Chemistry","Cell","Membrane protein","Membrane","Biochemistry","Endocytosis","Integral membrane protein","Cholesterol","Calcium","Lysosome","Cell Membrane","Biological Transport","Endosomes","Lipid Metabolism","[SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]","Animals","Humans","Calcium Signaling"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T11:02:06.183101Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}