{"doi":"10.1016/j.bbalip.2012.09.009","title":"Phosphatidylcholine and the CDP–choline cycle","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","year":2013,"id":668535,"datarank":0.8414207692777441,"base_score":5.60947179518496,"endowment":5.60947179518496,"self_citation_contribution":0.8414207692777441,"citation_network_contribution":0.0,"self_endowment_contribution":0.8414207692777441,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":272,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":469114,"name":"Suzanne Jackowski","orcid":"0000-0002-6855-1429","position":1,"is_corresponding":false},{"id":1745777,"name":"Paolo Fagone","orcid":"0000-0002-6694-1992","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Phosphatidylcholine and the CDP–choline cycle","abstract":"The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago. Investigation of the CDP-choline pathway in yeast provides a basis for understanding the CDP-choline pathway in mammals. PtdCho is considered as an intermediate in a cycle of synthesis and degradation, and the activity of a CDP-choline cycle is linked to subcellular membrane lipid movement. The components of the mammalian CDP-choline pathway include choline transport, choline kinase, phosphocholine cytidylyltransferase, and choline phosphotransferase activities. The protein isoforms and biochemical mechanisms of regulation of the pathway enzymes are related to their cell- and tissue-specific functions. Regulated PtdCho turnover mediated by phospholipases or neuropathy target esterase participates in the mammalian CDP-choline cycle. Knockout mouse models define the biological functions of the CDP-choline cycle in mammalian cells and tissues. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.","is_dataset_classified":null,"base_score":5.60947179518496,"endowment":5.60947179518496,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23010477","pmcid":"PMC3562404","openalex_id":"https://openalex.org/W2091108957","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"GM062896","title":null},{"funder_name":"Cancer Center (CORE)","grant_id":"CA21765","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA021765","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM045737","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM062896","title":null},{"funder_name":"American Lebanese Syrian Associated Charities","grant_id":"","title":null}],"total_grants":6,"fwci":6.1892,"citation_percentile":0.96470588,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":4},{"year":2014,"count":13},{"year":2015,"count":15},{"year":2016,"count":19},{"year":2017,"count":23},{"year":2018,"count":21},{"year":2019,"count":21},{"year":2020,"count":27},{"year":2021,"count":27},{"year":2022,"count":20},{"year":2023,"count":16},{"year":2024,"count":28},{"year":2025,"count":25},{"year":2026,"count":11}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1388198112002065?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1388198112002065?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbalip.2012.09.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23010477","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3562404","host_type":"repository"}],"fields_of_study":["Neurological Disorders and Treatments","Biotin and Related Studies","Biochemical Acid Research Studies","Animals","Biological Transport","Cell Membrane","Choline","Choline Kinase","Choline-Phosphate Cytidylyltransferase","Cytidine Diphosphate Choline","Diglycerides","Endoplasmic Reticulum","Golgi Apparatus","Isoenzymes","Mice","Mice, Knockout","Phosphatidylcholines","Saccharomyces cerevisiae"],"mesh_terms":["Animals","Biological Transport","Cell Membrane","Choline","Choline Kinase","Cytidine Diphosphate Choline","Diglycerides","Endoplasmic Reticulum","Golgi Apparatus","Isoenzymes","Phosphatidylcholines","Saccharomyces cerevisiae","Mice, Knockout","Choline-Phosphate Cytidylyltransferase","Mice"],"keywords":["Phosphocholine","Choline kinase","Choline","Phosphatidylcholine","Biochemistry","PLD2","Biology","Cell biology","Phospholipid","Chemistry","Membrane"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-14T11:52:17.175240Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}