{"doi":"10.1016/j.bbagrm.2012.09.009","title":"A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","year":2013,"id":593992,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":247323,"name":"Alessandro Vannini","orcid":"0000-0001-7212-5425","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries","abstract":"RNA polymerase I and III are responsible for the bulk of nuclear transcription in actively growing cells and their activity impacts the cellular biosynthetic capacity. As a consequence, RNA polymerase I and III deregulation has been directly linked to cancer development. The complexity of RNA polymerase I and III transcription apparatuses has hampered their structural characterization. However, in the last decade tremendous progresses have been made, providing insights into the molecular and functional architecture of these multi-subunit transcriptional machineries. Here we summarize the available structural data on RNA polymerase I and III, including specific transcription factors and global regulators. Despite the overall scarcity of detailed structural data, the recent advances in the structural biology of RNA polymerase I and III represent the first step towards a comprehensive understanding of the molecular mechanism underlying RNA polymerase I and III transcription. This article is part of a Special Issue entitled: Transcription by Odd Pols.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23031840","pmcid":null,"openalex_id":"https://openalex.org/W2014299842","authors":[],"funders":[],"total_grants":0,"fwci":0.8591,"citation_percentile":0.7065703,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":4},{"year":2014,"count":2},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":3}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1874939912001691?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1874939912001691?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbagrm.2012.09.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23031840","host_type":"repository"}],"fields_of_study":["RNA and protein synthesis mechanisms","Bacteriophages and microbial interactions","Genomics and Chromatin Dynamics"],"mesh_terms":["Animals","Humans","Repressor Proteins","RNA Polymerase I","RNA Polymerase III","Transcription Factors","Transcription, Genetic"],"keywords":["RNA polymerase II","Transcription factor II D","RNA polymerase II holoenzyme","Polymerase","Transcription (linguistics)","RNA polymerase I","RNA polymerase","Biology","RNA polymerase III","Transcription factor II F","General transcription factor","Transcription factor II B","RNA-dependent RNA polymerase","Transcription factories","Cell biology","RNA","Molecular biology","Genetics","Gene expression","Promoter","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T13:05:31.656141Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}