{"doi":"10.1016/j.bbadis.2024.167559","title":"Overexpression of FBP1 enhances dendritic cell activation and maturation by inhibiting glycolysis and promoting the secretion of IL33 in lung adenocarcinoma","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","year":2025,"id":669952,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":134170,"name":"Lili Zhu","orcid":"0009-0003-4119-5270","position":1,"is_corresponding":false},{"id":1749748,"name":"Yaqi Yang","orcid":null,"position":2,"is_corresponding":false},{"id":107702,"name":"Tengfei Zhang","orcid":"0000-0002-7761-6159","position":3,"is_corresponding":false},{"id":1749749,"name":"Chengxin Chen","orcid":null,"position":4,"is_corresponding":false},{"id":1749750,"name":"Yixing Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":553321,"name":"Wenxuan Ji","orcid":null,"position":6,"is_corresponding":false},{"id":1749751,"name":"Xiaoran Duan","orcid":null,"position":7,"is_corresponding":false},{"id":28942,"name":"Wenhua Xue","orcid":null,"position":8,"is_corresponding":false},{"id":475228,"name":"Lifeng Li","orcid":"0000-0002-7492-4017","position":9,"is_corresponding":false},{"id":913691,"name":"Jie Zhao","orcid":"0000-0001-6536-5834","position":10,"is_corresponding":false},{"id":1749747,"name":"Chunwei Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Overexpression of FBP1 enhances dendritic cell activation and maturation by inhibiting glycolysis and promoting the secretion of IL33 in lung adenocarcinoma","abstract":"Fructose 1,6-diphosphatase 1 (FBP1) is an enzyme involved in gluconeogenesis and glycolysis inhibition. Dendritic cells (DCs) are antigen-presenting cells, and antigens presented to T cells activate the immune response. FBP1 inhibits the development of several tumors, and high FBP1 expression inhibits the proliferation, migration, and invasion of lung cancer cells. However, the mechanism through which FBP1 mediates the tumor immune microenvironment is unclear. This study mainly analyzed the role of FBP1 in regulating the function of DCs through metabolic reprogramming and immune microenvironment using in vitro and in vivo experiments. The positive association of FBP1 with DCs was found by bioinformatic analysis. The in vitro experiments revealed that the extracellular acidification rate and lactate level were lower in the FBP1 overexpression cells than in the control cells and that the lower lactate level reduced the inhibition of DC function. In addition, high FBP1 expression promoted the secretion of IL33 by activating the cGAS/STING/NF-κB/IL33 pathway, which was identified and verified via high-throughput sequencing and in vitro experiments. FBP1 activated the cGAS/STING pathway by increasing the degree of DNA damage, as revealed by the level of γH2AX and comet assay. IL33 enhanced the expression of the DC costimulatory molecules CD86 and HLA-DR as well as that of the functional factor IL-1β. The results demonstrated that FBP1 promoted the activation and maturation of DCs by inhibiting glycolysis and promoting the secretion of IL33 as well as by further activating the function of CD8 + T cells. Finally, the humanized immune system mouse models confirmed the above role of FBP1. Thus, FBP1 may serve as a new target to cure lung adenocarcinoma, and IL33 may improve the efficiency of immune therapy in lung adenocarcinoma. • FBP1 overexpression inhibits the secretion of lactate and promotes the production of IL33 in LUAD cells. • FBP1 overexpression activates the cGAS/STING/NF-κB/IL33 pathway by increasing DNA damage. • FBP1 overexpression enhances DC activation and maturation. • FBP1 may serve as a new target to cure LUAD.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39486659","pmcid":null,"openalex_id":"https://openalex.org/W4403936333","authors":[],"funders":[{"funder_name":"Wu Jieping Medical Foundation","grant_id":"320.6750.2023-02-1","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32370976","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82002433","title":null},{"funder_name":"Key Scientific Research Project of Colleges and Universities in Henan Province","grant_id":"22A416012","title":null},{"funder_name":"Key Research and Development Program of Hunan Province of China","grant_id":"","title":null}],"total_grants":5,"fwci":1.6499,"citation_percentile":0.85064046,"influential_citations":0,"citation_trend":[{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.1016/j.bbadis.2024.167559","host_type":"journal"},{"url":"https://doi.org/10.1016/j.bbadis.2024.167559","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0925443924005532?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0925443924005532?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39486659","host_type":"repository"}],"fields_of_study":["Cancer-related molecular mechanisms research","interferon and immune responses","Immunotherapy and Immune Responses","Dendritic Cells","Humans","Glycolysis","Adenocarcinoma of Lung","Lung Neoplasms","Fructose-Bisphosphatase","Animals","Mice","Tumor Microenvironment","Cell Line, Tumor","Gene Expression Regulation, Neoplastic","Signal Transduction","Nucleotidyltransferases","Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase"],"mesh_terms":["Adenocarcinoma of Lung","Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase","Animals","Dendritic Cells","Glycolysis","Fructose-Bisphosphatase","Humans","Lung Neoplasms","Nucleotidyltransferases","Signal Transduction","Gene Expression Regulation, Neoplastic","Cell Line, Tumor","Mice","Tumor Microenvironment"],"keywords":["Secretion","Glycolysis","Cell biology","Lung","Adenocarcinoma","Dendritic cell","Cancer research","Chemistry","Biology","Metabolism","Internal medicine","Immunology","Biochemistry","Cancer","Medicine","Antigen","Genetics","Dendritic cells","Lactate","Lung adenocarcinoma","Il33","Cgas/sting","Fructose 1,6-Diphosphatase 1"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T10:39:40.924558Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}