{"doi":"10.1016/j.bbadis.2009.06.008","title":"Impaired mitochondrial trafficking in Huntington's disease","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","year":2010,"id":47203,"datarank":2.448256991549095,"base_score":4.23410650459726,"endowment":4.23410650459726,"self_citation_contribution":0.635115975689589,"citation_network_contribution":1.813141015859506,"self_endowment_contribution":0.635115975689589,"citer_contribution":1.813141015859506,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":67,"citers_with_citation_signal":58,"citers_with_endowment":58,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":217801,"name":"Adam L. Orr","orcid":null,"position":1,"is_corresponding":false},{"id":141899,"name":"Shihua Li","orcid":null,"position":2,"is_corresponding":false},{"id":141898,"name":"Xiao-Jiang Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Impaired mitochondrial trafficking in Huntington's disease","abstract":"Impaired mitochondrial function has been well documented in Huntington's disease. Mutant huntingtin is found to affect mitochondria via various mechanisms including the dysregulation of gene transcription and impairment of mitochondrial function or trafficking. The lengthy and highly branched neuronal processes constitute complex neural networks in which there is a large demand for mitochondria-generated energy. Thus, the impaired mitochondrial trafficking in neuronal cells may play an important role in the selective neuropathology of Huntington's disease. Here we discuss the evidence for the effect of the Huntington's disease protein huntingtin on the intracellular trafficking of mitochondria and the involvement of this defective trafficking in the pathogenesis of Huntington's disease.","is_dataset_classified":null,"base_score":4.23410650459726,"endowment":4.23410650459726,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19591925","pmcid":"PMC2790549","openalex_id":"https://openalex.org/W2146763467","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"NS041669","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS036232","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS041669","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS045016","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG019206","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG019206","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG031153","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS045016","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS036232","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R56 AG019206","title":null}],"total_grants":10,"fwci":2.4296,"citation_percentile":0.88633461,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":2},{"year":2014,"count":4},{"year":2015,"count":4},{"year":2016,"count":1},{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"https://hal.science/hal-00562910","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc2790549?pdf=render","host_type":"GREEN"},{"url":"https://hal.science/hal-00562910","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0925443909001434?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0925443909001434?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbadis.2009.06.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19591925","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2790549","host_type":"repository"},{"url":"http://hdl.handle.net/2262/50121","host_type":"repository"}],"fields_of_study":["Genetic Neurodegenerative Diseases","Mitochondrial Function and Pathology","Neurological disorders and treatments","Medicine","Biology","Animals","Humans","Huntington Disease","Mitochondria","Mitochondrial Proteins","Models, Biological","Protein Transport"],"mesh_terms":["Animals","Humans","Huntington Disease","Mitochondria","Models, Biological","Protein Transport","Mitochondrial Proteins"],"keywords":["Huntingtin","Huntington's disease","Mitochondrion","Huntingtin Protein","Neuropathology","Biology","DNAJA3","Cell biology","Neuroscience","Disease","Neurodegeneration","mitochondrial fusion","Genetics","Gene","Mitochondrial DNA","Medicine","Pathology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-17T23:46:10.258876Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}