{"doi":"10.1016/j.bbabio.2016.01.017","title":"BCL-2 family proteins as regulators of mitochondria metabolism","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Bioenergetics","year":2016,"id":681241,"datarank":0.7312795984801728,"base_score":4.875197323201151,"endowment":4.875197323201151,"self_citation_contribution":0.7312795984801728,"citation_network_contribution":0.0,"self_endowment_contribution":0.7312795984801728,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":130,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1779905,"name":"Atan Gross","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"BCL-2 family proteins as regulators of mitochondria metabolism","abstract":"The BCL-2 family proteins are major regulators of apoptosis, and one of their major sites of action are the mitochondria. Mitochondria are the cellular hubs for metabolism and indeed selected BCL-2 family proteins also possess roles related to mitochondria metabolism and dynamics. Here we discuss the link between mitochondrial metabolism/dynamics and the fate of stem cells, with an emphasis on the role of the BID-MTCH2 pair in regulating this link. We also discuss the possibility that BCL-2 family proteins act as metabolic sensors/messengers coming on and off of mitochondria to \"sample\" the cytosol and provide the mitochondria with up-to-date metabolic information. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.","is_dataset_classified":null,"base_score":4.875197323201151,"endowment":4.875197323201151,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26827940","pmcid":null,"openalex_id":"https://openalex.org/W2290255978","authors":[],"funders":[{"funder_name":"Israel Science Foundation (ISF)","grant_id":"1002/15","title":null},{"funder_name":"USA-Israel Binational Science Foundation (BSF)","grant_id":"2009/093","title":null},{"funder_name":"German-Israel Foundation (GIF)","grant_id":"1106-70.11/2010","title":null},{"funder_name":"Minerva Stiftung","grant_id":"711422","title":null},{"funder_name":"Hyman T. Milgrom Trust","grant_id":"","title":null},{"funder_name":"Rising Tide Trust","grant_id":"","title":null},{"funder_name":"Merlo and Adelis Foundations","grant_id":"","title":null},{"funder_name":"MDM ICR Research award","grant_id":"","title":null}],"total_grants":8,"fwci":10.75,"citation_percentile":0.98755391,"influential_citations":0,"citation_trend":[{"year":2016,"count":9},{"year":2017,"count":20},{"year":2018,"count":19},{"year":2019,"count":19},{"year":2020,"count":14},{"year":2021,"count":18},{"year":2022,"count":9},{"year":2023,"count":7},{"year":2024,"count":4},{"year":2025,"count":6},{"year":2026,"count":5}],"oa_status":"bronze","license":"https://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0005272816300196/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0005272816300196/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0005272816300196?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0005272816300196?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbabio.2016.01.017","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26827940","host_type":"repository"}],"fields_of_study":["Mitochondrial Function and Pathology","Cell death mechanisms and regulation","Autophagy in Disease and Therapy"],"mesh_terms":["Calcium","Cell Differentiation","Gene Expression Regulation","Humans","Mitochondria","Stem Cells","Apoptosis","Proto-Oncogene Proteins c-bcl-2","Calcium Signaling","Mitochondrial Membrane Transport Proteins","Cell Proliferation","bcl-2 Homologous Antagonist-Killer Protein","BH3 Interacting Domain Death Agonist Protein","bcl-2-Associated X Protein","Ataxia Telangiectasia Mutated Proteins"],"keywords":["Mitochondrion","Bcl-2 family","Bioenergetics","Cell biology","Biology","Cytosol","Metabolism","Apoptosis","Programmed cell death","Biochemistry","Enzyme","bcl-2","Bid","Stem Cells","Mtch2","Mitochondria Metabolism"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T17:17:32.094231Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}