{"doi":"10.1016/j.bbabio.2009.06.004","title":"SR/ER–mitochondrial local communication: Calcium and ROS","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Bioenergetics","year":2009,"id":682509,"datarank":0.8590271621380796,"base_score":5.726847747587197,"endowment":5.726847747587197,"self_citation_contribution":0.8590271621380796,"citation_network_contribution":0.0,"self_endowment_contribution":0.8590271621380796,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":306,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":316832,"name":"György Hajnóczky","orcid":"0000-0003-3813-2570","position":1,"is_corresponding":false},{"id":445272,"name":"György Csordás","orcid":"0000-0003-3156-1460","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"SR/ER–mitochondrial local communication: Calcium and ROS","abstract":"Mitochondria form junctions with the sarco/endoplasmic reticulum (SR/ER), which support signal transduction and biosynthetic pathways and affect organellar distribution. Recently, these junctions have received attention because of their pivotal role in mediating calcium signal propagation to the mitochondria, which is important for both ATP production and mitochondrial cell death. Many of the SR/ER-mitochondrial calcium transporters and signaling proteins are sensitive to redox regulation and are directly exposed to the reactive oxygen species (ROS) produced in the mitochondria and SR/ER. Although ROS has been emerging as a novel signaling entity, the redox signaling of the SR/ER-mitochondrial interface is yet to be elucidated. We describe here possible mechanisms of the mutual interaction between local Ca(2+) and ROS signaling in the control of SR/ER-mitochondrial function.","is_dataset_classified":null,"base_score":5.726847747587197,"endowment":5.726847747587197,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19527680","pmcid":"PMC2738971","openalex_id":"https://openalex.org/W1997759034","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK051526","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM059419","title":null}],"total_grants":2,"fwci":8.4408,"citation_percentile":0.98473771,"influential_citations":0,"citation_trend":[{"year":2012,"count":20},{"year":2013,"count":27},{"year":2014,"count":24},{"year":2015,"count":18},{"year":2016,"count":25},{"year":2017,"count":17},{"year":2018,"count":14},{"year":2019,"count":23},{"year":2020,"count":20},{"year":2021,"count":10},{"year":2022,"count":14},{"year":2023,"count":18},{"year":2024,"count":8},{"year":2025,"count":13},{"year":2026,"count":8}],"oa_status":"bronze","license":"https://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0005272809002059/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0005272809002059/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0005272809002059?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0005272809002059?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbabio.2009.06.004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19527680","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738971","host_type":"repository"}],"fields_of_study":["Mitochondrial Function and Pathology","ATP Synthase and ATPases Research","Metabolism and Genetic Disorders","Animals","Calcium","Calcium Signaling","Endoplasmic Reticulum","Humans","Inositol 1,4,5-Trisphosphate Receptors","Mitochondria","Reactive Oxygen Species","Ryanodine Receptor Calcium Release Channel","Sarcoplasmic Reticulum","Sarcoplasmic Reticulum Calcium-Transporting ATPases"],"mesh_terms":["Animals","Calcium","Endoplasmic Reticulum","Humans","Mitochondria","Sarcoplasmic Reticulum","Reactive Oxygen Species","Ryanodine Receptor Calcium Release Channel","Calcium Signaling","Inositol 1,4,5-Trisphosphate Receptors","Sarcoplasmic Reticulum Calcium-Transporting ATPases"],"keywords":["Cell biology","Mitochondrion","Endoplasmic reticulum","Calcium signaling","Reactive oxygen species","Signal transduction","Calcium","Mitochondrial ROS","Biology","Cell signaling","Chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T20:35:13.699088Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}