{"doi":"10.1016/j.bbabio.2006.11.013","title":"VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles","abstract":null,"journal":"Biochimica et Biophysica Acta (BBA) - Bioenergetics","year":2007,"id":653670,"datarank":0.6261580904843456,"base_score":4.174387269895637,"endowment":4.174387269895637,"self_citation_contribution":0.6261580904843456,"citation_network_contribution":0.0,"self_endowment_contribution":0.6261580904843456,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1705546,"name":"Zong-Jin Cai","orcid":null,"position":1,"is_corresponding":false},{"id":179507,"name":"William J. Craigen","orcid":null,"position":2,"is_corresponding":false},{"id":1705545,"name":"Keltoum Anflous-Pharayra","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles","abstract":"Voltage-dependent anion channels (VDACs), also known as mitochondrial porins, are the main pathway for metabolites across the mitochondrial outer membrane and may serve as binding sites for kinases, including hexokinase. We determined that mitochondria-bound hexokinase activity is significantly reduced in oxidative muscles (heart and soleus) in vdac1(-/-) mice. The activity data were supported by western blot analysis using HK2 specific antibody. To gain more insight into the physiologic mean of the results with the activity data, VDAC deficient mice were subjected to glucose tolerance testing and exercise-induced stress, each of which involves tissue glucose uptake via different mechanisms. vdac1(-/-) mice exhibit impaired glucose tolerance whereas vdac3(-/-) mice have normal glucose tolerance and exercise capacity. Mice lacking both VDAC1 and VDAC3 (vdac1(-/-)/vdac3(-/-)) have reduced exercise capacity together with impaired glucose tolerance. Therefore, we demonstrated a link between VDAC1 mediated mitochondria-bound hexokinase activity and the capacity for glucose clearance.","is_dataset_classified":null,"base_score":4.174387269895637,"endowment":4.174387269895637,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17207767","pmcid":null,"openalex_id":"https://openalex.org/W2106204941","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS42319","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM55713","title":null},{"funder_name":"National Institutes of Health","grant_id":"2R01NS042319-05A2","title":"The Role of Mitochondrial VDACs in Apoptosis"},{"funder_name":"National Institutes of Health","grant_id":"1R01GM055713-01","title":"GENETIC APPROACHES TO MITOCHONDRIAL VDAC FUNCTION"}],"total_grants":4,"fwci":1.4857,"citation_percentile":0.80729315,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":4},{"year":2014,"count":5},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":5},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0005272806003604?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0005272806003604?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bbabio.2006.11.013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17207767","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.bbabio.2006.11.013","host_type":""},{"url":"https://dx.doi.org/10.1016/j.bbabio.2006.11.013","host_type":""}],"fields_of_study":["Mitochondrial Function and Pathology","Adipose Tissue and Metabolism","Metabolism, Diabetes, and Cancer","0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":["Animals","Binding Sites","Female","Glucose Tolerance Test","Hexokinase","Male","Mitochondria, Muscle","Motor Activity","Myocardium","Blotting, Western","Muscle, Skeletal","Mitochondrial Proteins","Mitochondrial Membrane Transport Proteins","Voltage-Dependent Anion Channels","Voltage-Dependent Anion Channel 1","Mice"],"keywords":["VDAC1","Voltage-dependent anion channel","Hexokinase","Mitochondrion","Western blot","Biochemistry","Cell biology","Oxidative phosphorylation","Biology","Chemistry","Glycolysis","Bacterial outer membrane","Metabolism","Male","Blotting, Western","Biophysics","Motor Activity","Glucose clearance","Mitochondrial Membrane Transport Proteins","Mitochondrial Proteins","Mice","Exercise capacity","Animals","Voltage-Dependent Anion Channels","Muscle, Skeletal","Binding Sites","Myocardium","Voltage-Dependent Anion Channel 1","Porin","Glucose Tolerance Test","Mitochondria, Muscle","Mitochondrial outer membrane","Muscle","Female"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T23:45:35.642947Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}