{"doi":"10.1016/j.autrev.2008.03.009","title":"Natural and disease associated anti-myeloperoxidase (MPO) autoantibodies","abstract":null,"journal":"Autoimmunity Reviews","year":2008,"id":630476,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1171232,"name":"Amélie Servettaz","orcid":null,"position":1,"is_corresponding":false},{"id":558871,"name":"Frédéric Batteux","orcid":"0000-0002-1265-7996","position":2,"is_corresponding":false},{"id":1546061,"name":"Loïc Guillevin","orcid":null,"position":3,"is_corresponding":false},{"id":155860,"name":"Luc Mouthon","orcid":null,"position":4,"is_corresponding":false},{"id":1546057,"name":"Philippe Guilpain","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Natural and disease associated anti-myeloperoxidase (MPO) autoantibodies","abstract":"Myeloperoxidase (MPO) is a cationic protein present in primary azurophilic granules of neutrophils and monocytes. MPO produces a highly deleterious reactive oxygen species, the hypochlorous acid (HOCl), using hydrogen peroxide (H(2)O(2)) and chloride ions as substrate. Anti-MPO antibodies (Abs) are present in 70% of the cases in patients with microscopic polyangiitis (MPA), a small-sized vessel vasculitis. Anti-MPO Abs from patients with MPA can trigger the release of MPO by neutrophils and monocytes. Anti-MPO Abs can activate MPO to generate an oxidative stress deleterious for the endothelium. Thus, we recently demonstrated that MPA sera with anti-MPO Abs activated MPO in vitro, and generated hypochlorous acid, whereas sera from MPA patients with no anti-MPO Abs or healthy individuals did not. Both hypochlorous acid production and endothelial lysis were abrogated by N-acetylcysteine (NAC), an antioxidant molecule. Thus, anti-MPO Abs could play a pathogenic role in vivo by triggering an oxidative burst leading to severe endothelial damages.","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18558355","pmcid":null,"openalex_id":"https://openalex.org/W2067095417","authors":[],"funders":[],"total_grants":0,"fwci":2.6946,"citation_percentile":0.89765961,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":6},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2020,"count":3},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1568997208000360?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1568997208000360?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.autrev.2008.03.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18558355","host_type":"repository"}],"fields_of_study":["Vasculitis and related conditions","Sarcoidosis and Beryllium Toxicity Research","Autoimmune and Inflammatory Disorders","Animals","Autoantibodies","Autoimmune Diseases","Humans","Mice","Neutrophils","Peroxidase","Respiratory Burst","Vasculitis"],"mesh_terms":["Animals","Autoantibodies","Autoimmune Diseases","Humans","Peroxidase","Neutrophils","Vasculitis","Respiratory Burst","Mice"],"keywords":["Myeloperoxidase","Autoantibody","Disease","Immunology","Medicine","Antibody","Inflammation","Internal medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T21:25:18.396082Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}