{"doi":"10.1016/j.atssr.2024.07.010","title":"New-Onset Postoperative Atrial Fibrillation and Preoperative Sleep in Cardiac Surgical Patients","abstract":"Background New-onset postoperative atrial fibrillation is associated with adverse clinical outcomes in older adults. Poor preoperative sleep quality is a putative modifiable risk factor. The relationships between new-onset postoperative atrial fibrillation and preoperative sleep structure in older adults undergoing elective cardiac surgery were investigated at a single center. Methods This was a prespecified substudy within a prospective observational study of perioperative electroencephalographic markers (ClinicalTrials.gov; NCT03291626). We analyzed preoperative sleep recordings from 71 cardiac surgical patients aged ≥60 years without a prior history of atrial fibrillation. Overnight recordings were acquired using a consumer-grade headband and underwent manual sleep staging. Electroencephalographic slow wave activity (power in the 0.5-4 Hz frequency band) was computed in 1-minute intervals for non-rapid eye movement sleep stages. Associations between new-onset postoperative atrial fibrillation incidence and sleep measures were evaluated using univariate logistic regression models and multivariate logistic regression models including age and sex. Results New-onset postoperative atrial fibrillation was present in 22 of 71 (31%) patients. A higher preoperative percentage of total sleep time in non-rapid eye movement stage 1 was associated with new-onset postoperative atrial fibrillation (median difference of 5.4%, P = .0002, Mann-Whitney U-test), independent of age and sex. No associations were observed between new-onset postoperative atrial fibrillation and other sleep metrics, including slow wave activity (all P > .05, Mann-Whitney U-test). Conclusions Excess preoperative non-rapid eye movement stage 1 sleep, consistent with greater sleep fragmentation, is a potential modifiable target for mitigating new-onset postoperative atrial fibrillation risk in older adults undergoing elective cardiac surgery requiring cardiopulmonary bypass.","journal":"Annals of Thoracic Surgery Short Reports","year":2024,"id":501428,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6708,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03291626"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":411295,"name":"S. Kendall Smith","orcid":"0000-0003-0718-1150","position":1,"is_corresponding":false},{"id":1351141,"name":"Karishma Bhatia","orcid":null,"position":2,"is_corresponding":false},{"id":1351142,"name":"MohammedMehdi Kafashan","orcid":null,"position":3,"is_corresponding":false},{"id":411296,"name":"Thomas Nguyen","orcid":"0000-0002-3950-5546","position":4,"is_corresponding":false},{"id":412555,"name":"Orlandrea Hyche","orcid":null,"position":5,"is_corresponding":false},{"id":789937,"name":"Matthew R. Schill","orcid":"0000-0003-2131-9523","position":6,"is_corresponding":false},{"id":278782,"name":"Ralph J. Damiano","orcid":"0000-0002-6361-6107","position":7,"is_corresponding":false},{"id":302195,"name":"Ben Julian A. Palanca","orcid":"0000-0001-7535-5701","position":8,"is_corresponding":false},{"id":412558,"name":"Anhthi H. Luong","orcid":null,"position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T02:10:15.999370Z","pmid":"40098862","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}