{"doi":"10.1016/j.atherosclerosis.2022.11.014","title":"Galectin-9: A novel promoter of atherosclerosis progression","abstract":"BACKGROUND AND AIMS: Atherosclerosis is widely accepted to be an inflammatory disease driven by lipid accumulation and leukocyte recruitment. More recently, galectins, a family of β-galactoside binding proteins, have been shown to play a role in leukocyte recruitment among other immunomodulatory functions. Galectin (Gal) -9, a tandem repeat type galectin expressed by the endothelium in inflammatory environments, has been proposed to promote leukocyte recruitment. However, the role of Gal-9 in the context of monocyte recruitment remains elusive. METHODS AND RESULTS: monocytes in a β2-integrin and glycan dependent manner, while adhesion of monocytes to stimulated endothelium is reduced when Gal-9 is knocked down. Gal-9 also facilitates enhanced recruitment of leukocytes from peripheral arterial disease (PAD) patients compared to healthy young and aged controls. We further characterise the endothelium as source of circulating Gal-9, which is increased in plasma of PAD patients compared to healthy controls. CONCLUSIONS: These results highlight a pathological role for Gal-9 as promoter of monocyte recruitment and atherosclerotic plaque progression, making it a novel target in the prevention of plaque formation and progression.","journal":"Atherosclerosis","year":2022,"id":243216,"datarank":0.9682026573717386,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.4306748166033221,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.4306748166033221,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":30,"citers_with_citation_signal":25,"citers_with_endowment":25,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9635,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":874946,"name":"Mohammed T. Hussain","orcid":"0000-0002-8444-1414","position":1,"is_corresponding":false},{"id":874947,"name":"Zhaogong Zhi","orcid":"0000-0003-0896-1677","position":2,"is_corresponding":false},{"id":875606,"name":"Danielle Lezama","orcid":null,"position":3,"is_corresponding":false},{"id":875607,"name":"Julia E. Manning","orcid":null,"position":4,"is_corresponding":false},{"id":238961,"name":"Emily J. Brown","orcid":null,"position":5,"is_corresponding":false},{"id":875608,"name":"Noemi Marigliano","orcid":null,"position":6,"is_corresponding":false},{"id":875609,"name":"Federica Raucci","orcid":null,"position":7,"is_corresponding":false},{"id":874948,"name":"Carlota Recio","orcid":"0000-0002-8832-2826","position":8,"is_corresponding":false},{"id":874949,"name":"Myriam Chimen","orcid":"0000-0002-3567-1731","position":9,"is_corresponding":false},{"id":874950,"name":"Francesco Μaione","orcid":"0000-0003-2280-4299","position":10,"is_corresponding":false},{"id":875610,"name":"Alok Tiwari","orcid":null,"position":11,"is_corresponding":false},{"id":874951,"name":"Helen M. McGettrick","orcid":"0000-0002-5950-8840","position":12,"is_corresponding":false},{"id":874952,"name":"Dianne Cooper","orcid":"0000-0002-5553-9447","position":13,"is_corresponding":false},{"id":94623,"name":"Edward A. Fisher","orcid":"0000-0001-9802-143X","position":14,"is_corresponding":false},{"id":874953,"name":"Asif Iqbal","orcid":"0000-0002-3224-3651","position":15,"is_corresponding":false},{"id":874945,"name":"Franziska Krautter","orcid":"0000-0002-4666-7789","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:23:16.032700Z","pmid":"36459823","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}