{"doi":"10.1016/j.asjsur.2022.08.032","title":"Veno-arterial extracorporeal membrane oxygenation for the treatment of persistent pulmonary hypertension in the newborn","abstract":null,"journal":"Asian Journal of Surgery","year":2023,"id":685354,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1790553,"name":"Kyung Hee Park","orcid":null,"position":1,"is_corresponding":false},{"id":1790554,"name":"Heirim Lee","orcid":null,"position":2,"is_corresponding":false},{"id":1790556,"name":"Na Hyeon Lee","orcid":"0000-0001-5242-1454","position":3,"is_corresponding":false},{"id":1790551,"name":"Seunghwan Song","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Veno-arterial extracorporeal membrane oxygenation for the treatment of persistent pulmonary hypertension in the newborn","abstract":"Veno-arterial extracorporeal membrane oxygenation for the treatment of persistent pulmonary hypertension in the newbornTo the Editor, Persistent pulmonary hypertension of the newborn (PPHN) is caused by an abnormally high pulmonary vascular resistance due to failure of the pulmonary vasculature to adapt to extrauterine life, resulting in a right-to-left shunt in fetal circulation. 1 Most neonates with PPHN are diagnosed with respiratory distress and cyanosis shortly after birth.PPHN has been treated with supportive care, including mechanical ventilation, sedation, and acidosis correction. 2 If supportive care does not improve symptoms, vasodilatory agents (inhaled nitric oxide (iNO)) or extracorporeal membrane oxygenation (ECMO) may be necessary.A 37-week-gestation male infant, weighing 3,370 g, was delivered through a cesarean section at a local clinic, with no abnormalities on prenatal screening tests or during delivery.However, he presented with tachypnea, and desaturation after birth, and was transferred to our center.Hypoxemia and hypercapnia persisted despite ventilator care.Echocardiography showed a small secundum atrial septum defect with left-to-right dominant bidirectional shunt, significant tricuspid regurgitation, right ventricular dilatation, and flat interventricular septum, suggesting PPHN (Fig. 1A).His oxygen demand remained high despite high-frequency oscillatory ventilation (HFOV) and iNO; his vital signs were unstable despite maximally dosed inotropes and vasopressors.Venoarterial (VA) ECMO was instituted as follow-up echocardiogram showed decreased biventricular function compared to that the previous day.We inserted arterial and venous cannulas (8 and 12 Fr, respectively) with an open cut-down technique in the right common carotid artery and the right internal jugular vein (Fig. 1B) using small rubber pledgets between the suture and the vessel's proximal and distal part to improve fixation, reduce vessel damage, and facilitate repair during decannulation.Once started, the ECMO flow and blood pressure were maintained to reduce drug administration.Follow-up echocardiography after three days revealed improved ventricular function (Fig. 1C).Consequently, the patient was weaned off ECMO.Decannulation was performed using an open technique, and neck vessels were reconstructed without complications.The patient was weaned off the ventilator five days after ECMO removal and transferred to a general ward two days later.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36028404","pmcid":null,"openalex_id":"https://openalex.org/W4292877296","authors":[],"funders":[],"total_grants":0,"fwci":0.1361,"citation_percentile":0.45800011,"influential_citations":0,"citation_trend":[{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S1015958422011459/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S1015958422011459/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1015958422011459?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1015958422011459?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.asjsur.2022.08.032","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36028404","host_type":"repository"},{"url":"https://doaj.org/article/4f463ef660a742db9371f165904d9a31","host_type":"repository"}],"fields_of_study":["Pulmonary Hypertension Research and Treatments","Congenital Heart Disease Studies","Mechanical Circulatory Support Devices","Infant, Newborn","Humans","Extracorporeal Membrane Oxygenation","Hypertension, Pulmonary"],"mesh_terms":["Humans","Hypertension, Pulmonary","Infant, Newborn","Extracorporeal Membrane Oxygenation"],"keywords":["Medicine","Extracorporeal membrane oxygenation","Persistent pulmonary hypertension","Pulmonary hypertension","Oxygenation","Cardiology","Extracorporeal circulation","Internal medicine","Intensive care medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T16:26:35.999607Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}