{"doi":"10.1016/j.arr.2023.101962","title":"Cerebral small vessel disease pathology in COVID-19 patients: A systematic review","abstract":"Cerebral small vessel disease (CSVD) is the leading cause of vascular cognitive impairment and is associated with COVID-19. However, contributing factors that often accompany CSVD pathology in COVID-19 patients may influence the incidence of cerebrovascular complications. Thus, a mechanism linking COVID-19 and CSVD has yet to be uncovered and differentiated from age-related comorbidities (i.e., hypertension), and medical interventions during acute infection. We aimed to evaluate CSVD in acute and recovered COVID-19 patients and to differentiate COVID-19-related cerebrovascular pathology from the above-mentioned contributing factors by assessing the localization of microbleeds and ischemic lesions/infarctions in the cerebrum, cerebellum, and brainstem. A systematic search was performed in December 2022 on PubMed, Web of Science, and Embase using a pre-established search criterion related to history of, or active COVID-19 with CSVD pathology in adults. From a pool of 161 studies, 59 met eligibility criteria and were included. Microbleeds and ischemic lesions had a strong predilection for the corpus callosum and subcortical/deep white matter in COVID-19 patients, suggesting a distinct CSVD pathology. These findings have important implications for clinical practice and biomedical research as COVID-19 may independently, and through exacerbation of age-related mechanisms, contribute to increased incidence of CSVD.","journal":"Ageing Research Reviews","year":2023,"id":332774,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":310354,"name":"Camila Bonin Pinto","orcid":"0000-0003-2820-8703","position":1,"is_corresponding":false},{"id":887655,"name":"Sam Detwiler","orcid":null,"position":2,"is_corresponding":false},{"id":650179,"name":"Péter Mukli","orcid":"0000-0003-4355-8103","position":3,"is_corresponding":false},{"id":1034611,"name":"Anna Péterfi","orcid":"0000-0002-2455-5823","position":4,"is_corresponding":false},{"id":1034610,"name":"Z Szarvas","orcid":"0000-0002-0022-5053","position":5,"is_corresponding":false},{"id":887104,"name":"Jordan Hoffmeister","orcid":"0000-0002-0227-1926","position":6,"is_corresponding":false},{"id":1034613,"name":"Juliette Galindo","orcid":"0000-0002-1606-3765","position":7,"is_corresponding":false},{"id":1059416,"name":"Jila Noori","orcid":"0000-0001-5696-7913","position":8,"is_corresponding":false},{"id":887105,"name":"Angelia Kirkpatrick","orcid":"0000-0003-2500-6380","position":9,"is_corresponding":false},{"id":240664,"name":"Tarun W. Dasari","orcid":"0000-0002-4204-1279","position":10,"is_corresponding":false},{"id":226234,"name":"Judith A. James","orcid":"0000-0002-9574-7355","position":11,"is_corresponding":false},{"id":650181,"name":"Stefano Tarantini","orcid":"0000-0001-5627-1430","position":12,"is_corresponding":false},{"id":650186,"name":"Anna Csiszár","orcid":"0000-0003-4842-6660","position":13,"is_corresponding":false},{"id":650187,"name":"Zoltán Ungvári","orcid":"0000-0002-6035-6039","position":14,"is_corresponding":false},{"id":887106,"name":"Călin I. Prodan","orcid":"0000-0002-7749-2061","position":15,"is_corresponding":false},{"id":486200,"name":"Andriy Yabluchanskiy","orcid":"0000-0002-9648-7161","position":16,"is_corresponding":false},{"id":650178,"name":"Cameron D. Owens","orcid":"0000-0002-5020-2810","position":0,"is_corresponding":true}],"reference_count":195,"raw_metadata":null,"created_at":"2026-07-19T01:09:35.125543Z","pmid":"37224885","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}