{"doi":"10.1016/j.apsb.2023.08.014","title":"Immunostimulatory gene therapy combined with checkpoint blockade reshapes tumor microenvironment and enhances ovarian cancer immunotherapy","abstract":null,"journal":"Acta Pharmaceutica Sinica B","year":2024,"id":634708,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":683781,"name":"Xiang Wang","orcid":"0000-0003-4603-7186","position":1,"is_corresponding":false},{"id":1646295,"name":"Shi He","orcid":"0009-0002-8007-0000","position":2,"is_corresponding":false},{"id":1646296,"name":"Zhongxin Duan","orcid":null,"position":3,"is_corresponding":false},{"id":1646297,"name":"Yunchu Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":955900,"name":"Xiaodong Sun","orcid":"0000-0002-0034-9160","position":5,"is_corresponding":false},{"id":1646298,"name":"Yuzhu Hu","orcid":null,"position":6,"is_corresponding":false},{"id":735348,"name":"Yuanyuan Zhang","orcid":"0000-0002-9263-6262","position":7,"is_corresponding":false},{"id":1646299,"name":"Zhiyong Qian","orcid":null,"position":8,"is_corresponding":false},{"id":1170113,"name":"Xiang Gao","orcid":"0000-0002-0131-7857","position":9,"is_corresponding":false},{"id":944959,"name":"Zhirong Zhang","orcid":"0000-0001-9118-5394","position":10,"is_corresponding":false},{"id":1646293,"name":"Yunzhu Lin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Immunostimulatory gene therapy combined with checkpoint blockade reshapes tumor microenvironment and enhances ovarian cancer immunotherapy","abstract":"Immune evasion has made ovarian cancer notorious for its refractory features, making the development of immunotherapy highly appealing to ovarian cancer treatment. The immune-stimulating cytokine IL-12 exhibits excellent antitumor activities. However, IL-12 can induce IFN-γ release and subsequently upregulate PDL-1 expression on tumor cells. Therefore, the tumor-targeting folate-modified delivery system F-DPC is constructed for concurrent delivery of IL-12 encoding gene and small molecular PDL-1 inhibitor (iPDL-1) to reduce immune escape and boost anti-tumor immunity. The physicochemical characteristics, gene transfection efficiency of the F-DPC nanoparticles in ovarian cancer cells are analyzed. The immune-modulation effects of combination therapy on different immune cells are also studied. Results show that compared with non-folate-modified vector, folate-modified F-DPC can improve the targeting of ovarian cancer and enhance the transfection efficiency of pIL-12. The underlying anti-tumor mechanisms include the regulation of T cells proliferation and activation, NK activation, macrophage polarization and DC maturation. The F-DPC/pIL-12/iPDL-1 complexes have shown outstanding antitumor effects and low toxicity in peritoneal model of ovarian cancer in mice. Taken together, our work provides new insights into ovarian cancer immunotherapy. Novel F-DPC/pIL-12/iPDL-1 complexes are revealed to exert prominent anti-tumor effect by modulating tumor immune microenvironment and preventing immune escape and might be a promising treatment option for ovarian cancer treatment.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38322330","pmcid":"PMC10840399","openalex_id":"https://openalex.org/W4386002622","authors":[],"funders":[{"funder_name":"Sichuan Province Science and Technology Support Program","grant_id":"2022YFH0045","title":null},{"funder_name":"Sichuan Province Science and Technology Support Program","grant_id":"2022YFH0102","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32222046","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82170844","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82172630","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82270613","title":null},{"funder_name":"Sichuan University","grant_id":"ZYJC21022","title":null},{"funder_name":"West China Hospital, Sichuan University","grant_id":"","title":null}],"total_grants":8,"fwci":2.271,"citation_percentile":0.89450084,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":8},{"year":2025,"count":14},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.apsb.2023.08.014","host_type":"journal"},{"url":"https://doi.org/10.1016/j.apsb.2023.08.014","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211383523003180?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211383523003180?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38322330","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10840399","host_type":"repository"},{"url":"https://doaj.org/article/ee21c7a972504eaab4050b87a52404dd","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10840399/pdf/main.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10840399","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10840399?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Immunotherapy and Immune Responses","Cancer Immunotherapy and Biomarkers","Immune Cell Function and Interaction"],"mesh_terms":[],"keywords":["Ovarian cancer","Immune system","Tumor microenvironment","Cancer research","Immunotherapy","Cytokine","Cancer immunotherapy","Cancer","Medicine","Immunology","Biology","Internal medicine","Nanoparticles","Immune escape","Targeted Delivery","Checkpoint Blocker","Il-12 Encoding Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:02:41.479148Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}