{"doi":"10.1016/j.apsb.2023.02.006","title":"Emerging trends in organ-on-a-chip systems for drug screening","abstract":"New drug discovery is under growing pressure to satisfy the demand from a wide range of domains, especially from the pharmaceutical industry and healthcare services. Assessment of drug efficacy and safety prior to human clinical trials is a crucial part of drug development, which deserves greater emphasis to reduce the cost and time in drug discovery. Recent advances in microfabrication and tissue engineering have given rise to organ-on-a-chip, an in vitro model capable of recapitulating human organ functions in vivo and providing insight into disease pathophysiology, which offers a potential alternative to animal models for more efficient pre-clinical screening of drug candidates. In this review, we first give a snapshot of general considerations for organ-on-a-chip device design. Then, we comprehensively review the recent advances in organ-on-a-chip for drug screening. Finally, we summarize some key challenges of the progress in this field and discuss future prospects of organ-on-a-chip development. Overall, this review highlights the new avenue that organ-on-a-chip opens for drug development, therapeutic innovation, and precision medicine.","journal":"Acta Pharmaceutica Sinica B","year":2023,"id":316146,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":22887,"name":"Yanping Wang","orcid":"0000-0001-6979-3625","position":1,"is_corresponding":false},{"id":1019415,"name":"Yanfeng Gao","orcid":"0000-0001-5972-8993","position":2,"is_corresponding":false},{"id":1019416,"name":"Yongchun Pan","orcid":"0000-0001-9567-657X","position":3,"is_corresponding":false},{"id":1020336,"name":"Dongtao Zhou","orcid":null,"position":4,"is_corresponding":false},{"id":1019417,"name":"Yuta Liu","orcid":"0009-0003-6723-9016","position":5,"is_corresponding":false},{"id":1019418,"name":"Yi Yin","orcid":"0000-0002-9745-1363","position":6,"is_corresponding":false},{"id":1019419,"name":"Jingjing Yang","orcid":"0000-0002-0715-8287","position":7,"is_corresponding":false},{"id":1019420,"name":"Yuzhen Wang","orcid":"0000-0001-6199-1053","position":8,"is_corresponding":false},{"id":1019421,"name":"Yujun Song","orcid":"0000-0001-6311-5364","position":10,"is_corresponding":false},{"id":1019414,"name":"Yanping Wang","orcid":"0000-0001-7171-0286","position":0,"is_corresponding":true}],"reference_count":223,"raw_metadata":null,"created_at":"2026-07-19T01:06:38.213358Z","pmid":"37425038","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}