{"doi":"10.1016/j.apmr.2025.09.023","title":"Validity of Scores From the 12-Item Multiple Sclerosis Walking Scale Among Young, Middle-Aged, and Older Adults With Multiple Sclerosis","abstract":"OBJECTIVE: To examine the construct validity of inferences from scores on the 12-item multiple sclerosis walking scale (MSWS-12) as a patient-reported outcome measure of walking dysfunction among young, middle-aged, and older adults with multiple sclerosis (MS). DESIGN: Cross-sectional, comparative research design. SETTING: University research laboratory. PARTICIPANTS: The sample included 187 participants (N=187) with MS who were categorized into young (20-39y, n=50), middle-aged (40-59y, n=83), and older (60-79y, n=54) adult age groups. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The participants completed the MSWS-12; the timed 25-foot walk, 6-minute walk, and timed Up and Go; and the Brief International Cognitive Assessment for MS. The data analyses were performed using IBM SPSS Version 29.0.2.0 for the iOS platform. RESULTS: =0.06) across the 3 age groups. MSWS-12 scores had strong partial correlations with timed 25-foot walk, 6-minute walk, and timed Up and Go in the overall sample (partial r's of 0.59, 0.66, 0.55, respectively) and across the 3 age groups, when controlling for Brief International Cognitive Assessment for MS outcomes. CONCLUSIONS: We provide new evidence for the construct validity of MSWS-12 scores as a patient-reported outcome measure of walking dysfunction across the adult lifespan in MS. Our results, in particular, support the application of the MSWS-12 in clinical research and practice involving older adults with MS who experience the combined effects of advanced age and MS disease progression.","journal":"Archives of Physical Medicine and Rehabilitation","year":2025,"id":577402,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9172,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":722322,"name":"Petra Šilić","orcid":"0000-0002-2807-0663","position":1,"is_corresponding":false},{"id":452938,"name":"Trinh L. T. Huynh","orcid":"0000-0002-8109-2394","position":2,"is_corresponding":false},{"id":441736,"name":"Brenda Jeng","orcid":"0000-0002-4522-1523","position":3,"is_corresponding":false},{"id":441740,"name":"Robert W. Motl","orcid":"0000-0003-0112-2803","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:58:04.622308Z","pmid":"41067373","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}