{"doi":"10.1016/j.apjtb.2016.03.005","title":"Antibacterial activity of Bixa orellana L. (achiote) against Streptococcus mutans and Streptococcus sanguinis","abstract":null,"journal":"Asian Pacific Journal of Tropical Biomedicine","year":2016,"id":617907,"datarank":0.6010999777848708,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":0.0,"self_endowment_contribution":0.6010999777848708,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1593698,"name":"Gabriela Ulloa-Urizar","orcid":null,"position":1,"is_corresponding":false},{"id":1593699,"name":"Rosella Camere-Colarossi","orcid":null,"position":2,"is_corresponding":false},{"id":1593700,"name":"Stefany Caballero-García","orcid":null,"position":3,"is_corresponding":false},{"id":1593701,"name":"Frank Mayta-Tovalino","orcid":null,"position":4,"is_corresponding":false},{"id":1593702,"name":"Juana del Valle-Mendoza","orcid":null,"position":5,"is_corresponding":false},{"id":1593697,"name":"Dyanne Medina-Flores","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Antibacterial activity of Bixa orellana L. (achiote) against Streptococcus mutans and Streptococcus sanguinis","abstract":"Objective To evaluate the cytotoxic and antibacterial effect of Bixa orellana L. ( B. orellana ) (achiote) methanol extract against Streptococcus mutans (ATCC 25175) ( S. mutans ) and Streptococcus sanguinis (ATCC 10556) ( S. sanguinis ). Methods Two methanol extracts of B. orellana were prepared in vitro , from the seeds and leaves. The antibacterial activity of extracts against S. mutans and S. sanguinis was evaluated using the cup-plate agar diffusion method. The minimum inhibitory concentration (MIC) was determined using the microdilution method and the cytotoxic activity was determinated by using the cell line MDCK. Results A stronger antibacterial effect was observed with the leaves methanolic extract with an inhibition zone of (19.97 ± 1.31) mm against S. mutans and (19.97 ± 1.26) mm against S. sanguinis . The methanolic extract of the seeds had an activity of (15.11 ± 1.03) mm and (16.15 ± 2.15) mm against S. mutans and S. sanguinis , respectively. The MIC of the leaf and the seed extracts against S. sanguinis was 62.5 and 125 μg/mL, respectively, and the MIC of the leaf extract against S. mutans was 62.5 μg/mL, and for the seed extract it was 31.25 μg/mL. The 50% cytotoxic concentration was 366.45 and 325.05 μg/mL for the leaves and seeds extracts, respectively. Conclusions The experimental findings demonstrated the antibacterial effect of the methanolic extract of B. orellana (achiote) on S. mutans and S. sanguinis . The extract of this plant is cytotoxic at high concentrations.","is_dataset_classified":null,"base_score":4.007333185232471,"endowment":4.007333185232471,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19910364","pmcid":null,"openalex_id":"https://openalex.org/W2296871026","authors":[],"funders":[],"total_grants":0,"fwci":5.6156,"citation_percentile":0.94787497,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":7},{"year":2019,"count":5},{"year":2020,"count":5},{"year":2021,"count":9},{"year":2022,"count":6},{"year":2023,"count":9},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"diamond","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.apjtb.2016.03.005","host_type":"journal"},{"url":"http://api.elsevier.com/content/article/PII:S2221169115309485?httpAccept=text/xml","host_type":"publisher"},{"url":"http://api.elsevier.com/content/article/PII:S2221169115309485?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doaj.org/article/3b99b9d9130049278cf5de68a2985924","host_type":"repository"},{"url":"http://hdl.handle.net/10757/604437","host_type":"repository"},{"url":"https://zenodo.org/record/7140121","host_type":"repository"}],"fields_of_study":["Essential Oils and Antimicrobial Activity","Natural product bioactivities and synthesis","Bioactive Compounds and Antitumor Agents"],"mesh_terms":[],"keywords":["Streptococcus sanguinis","Streptococcus mutans","Antibacterial activity","Minimum inhibitory concentration","Traditional medicine","Agar diffusion test","Food science","Broth microdilution","Microbiology","Chemistry","Biology","Antimicrobial","Bacteria","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:55:01.726924Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}