{"doi":"10.1016/j.aohep.2020.01.005","title":"Alcohol, tobacco and coffee consumption and liver disease severity among individuals with Chronic Hepatitis B infection in North America","abstract":"INTRODUCTION AND OBJECTIVES: The prevalence of alcohol, tobacco, and coffee use and association with liver health among North Americans with Chronic Hepatitis B (CHB) infection has not been well described. MATERIALS AND METHODS: The Hepatitis B Research Network includes an observational study of untreated CHB adults enrolled at 21 sites in the United States and Canada. Alcohol use was categorized as none, moderate, and at-risk based on the definition from the National Institute on Alcohol Abuse and Alcoholism; tobacco use as never, current and former; coffee use as none, 1-2 cups/day, and ≥3 cups/day. Linear regression and linear mixed models were used to associate lifestyle behaviors with ALT and FIB-4 values. RESULTS: IU/mL, 71% were HBeAg negative, and 65% had a FIB-4 <1.45. At baseline, 8% of participants were at-risk alcohol drinkers, 11% were current smokers and 92% drank <3 cups of coffee/day. Current tobacco and 'at-risk' alcohol use, were significantly associated with elevated ALT levels in univariable analyses, however, these associations were not statistically significant when controlling for sociodemographic and HBV characteristics. CONCLUSIONS: In this large diverse cohort of untreated CHB participants, at-risk alcohol use, current tobacco use and limited coffee consumption did not have an association with high ALT and FIB-4 values. In contrast, significant associations were found between the frequency of these lifestyle behaviors and sociodemographic factors.","journal":"Annals of Hepatology","year":2020,"id":88792,"datarank":0.5785825762549519,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.233194812305845,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.233194812305845,"corpus_percentile":66.1096928908486,"corpus_rank":4382,"citation_count":9,"citer_count":9,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7185,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":297833,"name":"Stephen V. Liu","orcid":"0000-0002-4852-3914","position":1,"is_corresponding":false},{"id":449597,"name":"Abdus S. Wahed","orcid":"0000-0001-6911-7221","position":2,"is_corresponding":false},{"id":450528,"name":"Colina Yim","orcid":null,"position":3,"is_corresponding":false},{"id":280832,"name":"Bettina E. Hansen","orcid":"0000-0001-8307-3341","position":4,"is_corresponding":false},{"id":336587,"name":"Mandana Khalili","orcid":"0000-0001-9178-9139","position":5,"is_corresponding":false},{"id":253583,"name":"Norah A. Terrault","orcid":"0000-0003-4143-1950","position":6,"is_corresponding":false},{"id":262768,"name":"Anna S. Lok","orcid":"0000-0002-5811-6845","position":7,"is_corresponding":false},{"id":270560,"name":"Marc G. Ghany","orcid":"0000-0003-2837-0188","position":8,"is_corresponding":false},{"id":449598,"name":"Junyao Wang","orcid":"0000-0002-1567-6447","position":9,"is_corresponding":false},{"id":404034,"name":"David Wong","orcid":"0000-0002-3310-3538","position":10,"is_corresponding":false},{"id":270563,"name":"Harry L.A. Janssen","orcid":"0000-0003-2398-8392","position":11,"is_corresponding":false},{"id":449596,"name":"Mayur Brahmania","orcid":"0000-0002-4671-1479","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T22:01:22.387926Z","pmid":"32139262","pmcid":"PMC7757603","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}