{"doi":"10.1016/j.annepidem.2022.02.006","title":"A prospective study of preconception asthma and spontaneous abortion","abstract":"PURPOSE: To evaluate the relationships among history of asthma, asthma severity, and spontaneous abortion (SAB). METHODS: Pregnancy Study Online is a preconception cohort study of North American couples. During the preconception period, female participants reported their history of physician-diagnosed asthma, age at first diagnosis, and use of asthma medications in the previous 4 weeks. Asthma severity was classified by medication use proximal to conception, from level 0 to 3 in increasing severity. Pregnancy and SAB were identified using data from follow-up questionnaires. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Among 6325 participants who conceived, 19% experienced SAB and 17% reported a history of asthma. There was no appreciable association between asthma history and SAB incidence (HR = 0.98; 95% CI: 0.84, 1.14). HRs comparing severity levels 0, 1, and 2-3 with no asthma were 0.82 (95% CI: 0.67, 1.01), 1.20 (95% CI: 0.91, 1.60), and 1.31 (95% CI: 0.97, 1.78), respectively. Among women who conceived without the use of fertility treatment, level 2-3 severity was associated with SAB (HR = 1.39; 95% CI: 1.02, 1.89). CONCLUSIONS: While history of asthma diagnosis was not materially associated with SAB, having severe asthma (based on medication use) was associated with greater SAB risk.","journal":"Annals of Epidemiology","year":2022,"id":277564,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5013,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":758579,"name":"Holly M. Crowe","orcid":"0000-0001-9164-532X","position":1,"is_corresponding":false},{"id":371913,"name":"Elizabeth E. Hatch","orcid":"0000-0001-7901-3928","position":2,"is_corresponding":false},{"id":371911,"name":"Sydney K. Willis","orcid":"0000-0002-6858-5450","position":3,"is_corresponding":false},{"id":372995,"name":"Tanran R. Wang","orcid":null,"position":4,"is_corresponding":false},{"id":463277,"name":"Ellen M. Mikkelsen","orcid":"0000-0003-0158-7950","position":5,"is_corresponding":false},{"id":275870,"name":"David A. Savitz","orcid":"0000-0002-3475-4113","position":6,"is_corresponding":false},{"id":306786,"name":"Allan J. Walkey","orcid":"0000-0003-4685-6894","position":7,"is_corresponding":false},{"id":5904,"name":"Kenneth J. Rothman","orcid":"0000-0003-2398-1705","position":8,"is_corresponding":false},{"id":329832,"name":"Lauren A. Wise","orcid":"0000-0003-2138-3752","position":9,"is_corresponding":false},{"id":463276,"name":"Jennifer J. Yland","orcid":"0000-0001-7870-8971","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T00:28:39.226969Z","pmid":"35235814","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}