{"doi":"10.1016/j.annemergmed.2016.10.008","title":"Interpretation of Cerebrospinal Fluid White Blood Cell Counts in Young Infants With a Traumatic Lumbar Puncture","abstract":null,"journal":"Annals of Emergency Medicine","year":2017,"id":603005,"datarank":0.6038027536102726,"base_score":4.02535169073515,"endowment":4.02535169073515,"self_citation_contribution":0.6038027536102726,"citation_network_contribution":0.0,"self_endowment_contribution":0.6038027536102726,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":513302,"name":"Andrea T. 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Lyons","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interpretation of Cerebrospinal Fluid White Blood Cell Counts in Young Infants With a Traumatic Lumbar Puncture","abstract":"<h4>Study objective</h4>We determine the optimal correction factor for cerebrospinal fluid WBC counts in infants with traumatic lumbar punctures.<h4>Methods</h4>We performed a secondary analysis of a retrospective cohort of infants aged 60 days or younger and with a traumatic lumbar puncture (cerebrospinal fluid RBC count ≥10,000 cells/mm<sup>3</sup>) at 20 participating centers. Cerebrospinal fluid pleocytosis was defined as a cerebrospinal fluid WBC count greater than or equal to 20 cells/mm<sup>3</sup> for infants aged 28 days or younger and greater than or equal to 10 cells/mm<sup>3</sup> for infants aged 29 to 60 days; bacterial meningitis was defined as growth of pathogenic bacteria from cerebrospinal fluid culture. Using linear regression, we derived a cerebrospinal fluid WBC correction factor and compared the uncorrected with the corrected cerebrospinal fluid WBC count for the detection of bacterial meningitis.<h4>Results</h4>Of the eligible 20,319 lumbar punctures, 2,880 (14%) were traumatic, and 33 of these patients (1.1%) had bacterial meningitis. The derived cerebrospinal fluid RBCs:WBCs ratio was 877:1 (95% confidence interval [CI] 805 to 961:1). Compared with the uncorrected cerebrospinal fluid WBC count, the corrected one had lower sensitivity for bacterial meningitis (88% uncorrected versus 67% corrected; difference 21%; 95% CI 10% to 37%) but resulted in fewer infants with cerebrospinal fluid pleocytosis (78% uncorrected versus 33% corrected; difference 45%; 95% CI 43% to 47%). Cerebrospinal fluid WBC count correction resulted in the misclassification of 7 additional infants with bacterial meningitis, who were misclassified as not having cerebrospinal fluid pleocytosis; only 1 of these infants was older than 28 days.<h4>Conclusion</h4>Correction of the cerebrospinal fluid WBC count substantially reduced the number of infants with cerebrospinal fluid pleocytosis while misclassifying only 1 infant with bacterial meningitis of those aged 29 to 60 days.","is_dataset_classified":null,"base_score":4.02535169073515,"endowment":4.02535169073515,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28041826","pmcid":"PMC5406248","openalex_id":"https://openalex.org/W2565460586","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"T32 HD040128","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR001863","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"K23 HD082368","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"KL2 TR001862","title":null}],"total_grants":4,"fwci":4.2032,"citation_percentile":0.94096707,"influential_citations":0,"citation_trend":[{"year":2017,"count":5},{"year":2018,"count":7},{"year":2019,"count":6},{"year":2020,"count":9},{"year":2021,"count":1},{"year":2022,"count":7},{"year":2023,"count":4},{"year":2024,"count":9},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0196064416312239?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0196064416312239?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.annemergmed.2016.10.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28041826","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5406248","host_type":"repository"}],"fields_of_study":["Bacterial Infections and Vaccines","Cerebrospinal fluid and hydrocephalus","Child Abuse and Related Trauma","Bacteremia","Cerebrospinal Fluid","Female","Herpes Simplex","Humans","Infant","Infant, Newborn","Leukocyte Count","Male","Meningitis, Bacterial","Retrospective Studies","Spinal Puncture","Urinary Tract Infections"],"mesh_terms":["Cerebrospinal Fluid","Female","Herpes Simplex","Humans","Infant","Infant, Newborn","Leukocyte Count","Male","Retrospective Studies","Spinal Puncture","Urinary Tract Infections","Bacteremia","Meningitis, Bacterial"],"keywords":["Cerebrospinal fluid","Medicine","Pleocytosis","Lumbar puncture","Meningitis","White blood cell","Confidence interval","CSF pleocytosis","CSF albumin","Gastroenterology","Internal medicine","Surgery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T20:52:46.041365Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}