{"doi":"10.1016/j.anai.2018.12.013","title":"Seasonal exacerbation of eosinophilic esophagitis histologic activity in adults and children implicates role of aeroallergens","abstract":null,"journal":"Annals of Allergy, Asthma &amp; Immunology","year":2019,"id":615130,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1585335,"name":"Edward G.A. Iglesia","orcid":null,"position":1,"is_corresponding":false},{"id":463642,"name":"Scott P. Commins","orcid":"0000-0003-1198-2428","position":2,"is_corresponding":false},{"id":233047,"name":"Evan S. Dellon","orcid":"0000-0003-1167-1101","position":3,"is_corresponding":false},{"id":345575,"name":"Craig C. Reed","orcid":"0009-0004-1451-0746","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Seasonal exacerbation of eosinophilic esophagitis histologic activity in adults and children implicates role of aeroallergens","abstract":"<h4>Background</h4>Disease activity may correlate with environmental aeroallergen exposure in eosinophilic esophagitis. The association between seasons and flares of eosinophilic esophagitis (EoE) histologic activity has not been extensively studied.<h4>Objective</h4>We aimed to assess the frequency of seasonal exacerbations of eosinophilic esophagitis, as well as changes in symptom reporting, endoscopic findings, and histologic findings attributed to aeroallergens in an EoE cohort.<h4>Methods</h4>In this retrospective cohort study, we analyzed EoE patients in histologic remission (<15 eosinophil/high-power field) but who doubled the esophageal eosinophil count between seasons without change in eosinophilic esophagitis-specific therapy. Outcomes were: symptomatic global worsening (yes/no); change in endoscopic severity (EREFS scoring system); and histologic change (peak eosinophil count).<h4>Results</h4>Of 782 patients, 13 (4%) met inclusion criteria (mean age: 36.2; 85% male; 86% white; 85% atopic disease diagnosis), and 14 exacerbations were recorded. Of these, 71% occurred in fall and summer months. Peak eosinophil counts increased from 6.8 to 86.8 eosinophil per high-power field (P < .001). Four patients (31%) reported worsening of seasonal allergies and 5 (38%) a global worsening of symptoms. Endoscopic severity was also significantly worse during seasonal exacerbations (total EREFS 3.7 vs 1.7; P = .01). Baseline features differed by atopic diagnoses and endoscopic findings between patients with and without seasonal exacerbations.<h4>Conclusion</h4>Seasonal exacerbations of eosinophilic esophagitis were uncommon in this cohort and most commonly recorded over the summer and fall months. These data support a role of aeroallergens in the pathogenesis of eosinophilic esophagitis in some patients, and clinicians should consider aeroallergens as a potential cause of disease exacerbation.","is_dataset_classified":null,"base_score":4.343805421853684,"endowment":4.343805421853684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30578860","pmcid":"PMC6389386","openalex_id":"https://openalex.org/W2905275405","authors":[],"funders":[{"funder_name":"NIH","grant_id":"T32 DK007634","title":null},{"funder_name":"NIH","grant_id":"R01 DK101856","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"P30 ES010126","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK034987","title":null},{"funder_name":"Regeneron","grant_id":"","title":null},{"funder_name":"Shire","grant_id":"","title":null},{"funder_name":"Meritage","grant_id":"","title":null},{"funder_name":"Adare","grant_id":"","title":null},{"funder_name":"Nutricia","grant_id":"","title":null},{"funder_name":"Celgene","grant_id":"","title":null},{"funder_name":"Miraca","grant_id":"","title":null},{"funder_name":"Receptos","grant_id":"","title":null}],"total_grants":12,"fwci":6.8512,"citation_percentile":0.97720477,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2019,"count":7},{"year":2020,"count":12},{"year":2021,"count":12},{"year":2022,"count":8},{"year":2023,"count":12},{"year":2024,"count":13},{"year":2025,"count":7},{"year":2026,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1081120618315333?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1081120618315333?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.anai.2018.12.013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30578860","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6389386","host_type":"repository"}],"fields_of_study":["Eosinophilic Esophagitis","Food Allergy and Anaphylaxis Research","Eosinophilic Disorders and Syndromes"],"mesh_terms":["Adolescent","Adult","Air Pollutants","Allergens","Child","Child, Preschool","Endoscopy","Environmental Exposure","Esophagus","Female","Humans","Infant","Male","Middle Aged","Retrospective Studies","Seasons","Severity of Illness Index","Disease Progression","Young Adult","Eosinophilic Esophagitis"],"keywords":["Medicine","Eosinophilic esophagitis","Exacerbation","Dermatology","Esophagitis","Immunology","Pathology","Disease","Reflux"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T19:04:30.080343Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}