{"doi":"10.1016/j.amjsurg.2024.115779","title":"National practice patterns in the use of endoscopic ultrasound biopsy for resectable Pancreatic Neuroendocrine Tumors: Insights into the role of DOTATATE PET/CT in diagnosis","abstract":"INTRODUCTION: Pancreatic neuroendocrine tumors (PNETs) are typically diagnosed using endoscopic ultrasound-guided (EUS) biopsy, which can be associated with complications. Since 2016, DOTATATE PET/CT has emerged as an effective tool to localize and stage PNETs. METHODS: Patients with PNETs who underwent R0 resections were identified from the 2004-2019 National Cancer Database PUF. Joinpoint regression and multivariable logistic regression were used to analyze trends in the use of biopsy. RESULTS: Of 16,746 R0 resected PNET patients, 44 ​% underwent diagnostic biopsy. Joinpoint regression showed a significant increase in the use of biopsy from 2004 to 2019 (APC 1.80, p ​< ​0.001). A higher percentage of patients diagnosed after DOTATATE approval underwent biopsy compared to those diagnosed before (48 ​% vs. 42 ​%, p ​< ​0.001). Adjusted analysis showed diagnosis after 2016 was associated with increased odds of biopsy (OR ​= ​1.67, p ​< ​0.001). CONCLUSIONS: Despite technologic advancement with DOTATATE PET/CT, there has been a significant increase in the proportion of resectable PNETs undergoing preoperative biopsy.","journal":"The American Journal of Surgery","year":2024,"id":476827,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":962274,"name":"Audrey Brown","orcid":"0000-0002-6898-2114","position":1,"is_corresponding":false},{"id":1313295,"name":"Fernanda Romero‐Hernández","orcid":"0000-0001-6014-9251","position":2,"is_corresponding":false},{"id":546897,"name":"Jane Wang","orcid":"0000-0003-3705-3993","position":3,"is_corresponding":false},{"id":89478,"name":"Amir Ashraf‐Ganjouei","orcid":"0000-0003-2745-5032","position":4,"is_corresponding":false},{"id":849852,"name":"Francesca Tozzi","orcid":"0000-0003-1597-2681","position":5,"is_corresponding":false},{"id":1314312,"name":"Nikdokht Rashidian","orcid":"0000-0003-2654-4447","position":6,"is_corresponding":false},{"id":336041,"name":"Kimberly S. Kirkwood","orcid":"0000-0002-6876-2752","position":7,"is_corresponding":false},{"id":625669,"name":"Carlos U. Corvera","orcid":"0000-0002-3092-8657","position":8,"is_corresponding":false},{"id":625670,"name":"Eric K. Nakakura","orcid":"0009-0007-3714-7072","position":9,"is_corresponding":false},{"id":707585,"name":"Adnan Alseidi","orcid":"0000-0002-0365-1955","position":10,"is_corresponding":false},{"id":707586,"name":"Mohamed A. Adam","orcid":"0000-0002-0059-7615","position":11,"is_corresponding":false},{"id":519573,"name":"Megan Casey","orcid":"0000-0001-5984-9023","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:06:29.605760Z","pmid":"38811243","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}