{"doi":"10.1016/j.amjsurg.2019.10.013","title":"Clinically resectable acinar cell carcinoma of the pancreas: Is there a benefit to adjuvant systemic therapy?","abstract":null,"journal":"The American Journal of Surgery","year":2020,"id":676524,"datarank":1.7749358674507647,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":1.2550754820308057,"self_endowment_contribution":0.519860385419959,"citer_contribution":1.2550754820308057,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":31,"citers_with_citation_signal":24,"citers_with_endowment":24,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1261028,"name":"Waseem Lutfi","orcid":"0000-0001-8327-4127","position":1,"is_corresponding":false},{"id":327062,"name":"Patrick Sweigert","orcid":"0000-0001-9630-6482","position":2,"is_corresponding":false},{"id":327063,"name":"Emanuel Eguia","orcid":"0000-0003-0620-551X","position":3,"is_corresponding":false},{"id":532723,"name":"Gerard Abood","orcid":null,"position":4,"is_corresponding":false},{"id":1767646,"name":"Lawrence Knab","orcid":null,"position":5,"is_corresponding":false},{"id":415321,"name":"Paul C. Kuo","orcid":"0000-0002-2610-4233","position":6,"is_corresponding":false},{"id":327910,"name":"Marshall S. Baker","orcid":null,"position":7,"is_corresponding":false},{"id":1767644,"name":"Dhruv J. Patel","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinically resectable acinar cell carcinoma of the pancreas: Is there a benefit to adjuvant systemic therapy?","abstract":"BACKGROUND: Prior studies of adjuvant systemic therapy in pancreatic acinar cell carcinoma have been underpowered.\nMETHODS: We queried the National Cancer Data Base to identify patients presenting with resectable (clinical stage I and II) acinar cell carcinoma between 2004 and 2015. Multivariable Cox Regression was used to evaluate the association between overall survival and systemic therapy.\nRESULTS: 298 patients met inclusion criteria: 38 received no treatment; 60 received systemic therapy alone; 84 received surgical resection alone; 116 underwent resection followed by adjuvant systemic therapy. On univariate analysis, resection was associated with a survival benefit compared to no treatment and systemic therapy alone (3-year overall survival: 57% vs. 26%, p < 0.001). On Cox analysis, use of adjuvant therapy was associated with a survival benefit compared to resection alone (HR 0.54, 95% CI: 0.33-0.89).\nCONCLUSIONS: Adjuvant therapy is associated with a significant survival benefit in patients with resectable acinar cell carcinoma.","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31677782","pmcid":null,"openalex_id":"https://openalex.org/W2979630231","authors":[],"funders":[],"total_grants":0,"fwci":1.2527,"citation_percentile":0.8169592,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":7},{"year":2022,"count":5},{"year":2023,"count":7},{"year":2024,"count":5},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0002961019308335?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0002961019308335?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.amjsurg.2019.10.013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31677782","host_type":"repository"}],"fields_of_study":["Pancreatic and Hepatic Oncology Research","Pancreatitis Pathology and Treatment","Cholangiocarcinoma and Gallbladder Cancer Studies","Aged","Carcinoma, Acinar Cell","Chemotherapy, Adjuvant","Female","Humans","Lymphatic Metastasis","Male","Margins of Excision","Middle Aged","Neoplasm Staging","Pancreatectomy","Pancreatic Neoplasms","Survival Rate"],"mesh_terms":["Margins of Excision","Aged","Female","Humans","Lymphatic Metastasis","Male","Middle Aged","Neoplasm Staging","Pancreatectomy","Pancreatic Neoplasms","Survival Rate","Chemotherapy, Adjuvant","Carcinoma, Acinar Cell"],"keywords":["Medicine","Systemic therapy","Adjuvant therapy","Adjuvant","Internal medicine","Stage (stratigraphy)","Proportional hazards model","Oncology","Carcinoma","Pancreatic cancer","Pancreas","Univariate analysis","Cancer","Surgery","Multivariate analysis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T02:41:19.689620Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}