{"doi":"10.1016/j.alit.2014.12.008","title":"Proallergic cytokines and group 2 innate lymphoid cells in allergic nasal diseases","abstract":null,"journal":"Allergology International","year":2015,"id":605795,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1554840,"name":"Yukinori Kato","orcid":null,"position":1,"is_corresponding":false},{"id":1554842,"name":"Shoko Akasaki","orcid":null,"position":2,"is_corresponding":false},{"id":1554844,"name":"Tomohiro Yoshimoto","orcid":null,"position":3,"is_corresponding":false},{"id":754157,"name":"Kazufumi Matsushita","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Proallergic cytokines and group 2 innate lymphoid cells in allergic nasal diseases","abstract":"Recent advances in our understanding of proallergic cytokines and group 2 innate lymphoid cells (ILC2s) indicate their critical roles in type 2 immunity-mediated disorders. Proallergic cytokines, interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin, are released from epithelial cells in inflamed tissues and drive type 2 inflammation by acting on innate and acquired immune systems. ILC2s are an innate immune population that responds to proallergic cytokines by producing type 2 cytokines. In line with allergic disorders in the lung, skin, and intestine, emerging evidence suggests the involvement of proallergic cytokines and ILC2s in allergic nasal diseases such as chronic rhinosinusitis with polyps (CRSwNP), allergic fungal rhinosinusitis, and allergic rhinitis (AR). In CRSwNP patients, both proallergic cytokine levels and ILC2s frequency are increased in the nasal mucosa. Increased proallergic cytokine levels correlate with poorer disease outcomes in CRSwNP. Levels of nasal proallergic cytokines are also elevated in AR patients. In addition, animal studies demonstrate that cytokines are essential for the development of AR. It is becoming clear that the proallergic cytokine/ILC2s axis participates in allergic diseases by multiple mechanisms dependent upon the inflammatory context. Thus, a thorough understanding of these cytokines and ILC2s including their tissue- and disease-specific roles is essential for targeting the pathways to achieve therapeutic applications.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26117254","pmcid":null,"openalex_id":"https://openalex.org/W2078875613","authors":[],"funders":[{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"24390253","title":null},{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"S1001055","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"","title":null},{"funder_name":"Takeda Science Foundation","grant_id":"","title":null}],"total_grants":4,"fwci":0.8844,"citation_percentile":0.72540213,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.alit.2014.12.008","host_type":"journal"},{"url":"https://doi.org/10.1016/j.alit.2014.12.008","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1323893015000647?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1323893015000647?httpAccept=text/xml","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26117254","host_type":"repository"},{"url":"https://doaj.org/article/607a041c2929471e86ddad8fc4ad81cb","host_type":"repository"},{"url":"http://www.allergologyinternational.com/article/S1323893015000647/pdf","host_type":"Unpaywall"}],"fields_of_study":["IL-33, ST2, and ILC Pathways","Asthma and respiratory diseases","Eosinophilic Esophagitis"],"mesh_terms":["Animals","Chronic Disease","Humans","Hypersensitivity","Lymphocytes","Nasal Mucosa","Nasal Polyps","Sinusitis","Cytokines","Th2 Cells","Rhinitis, Allergic"],"keywords":["Innate lymphoid cell","Thymic stromal lymphopoietin","Immunology","Proinflammatory cytokine","Cytokine","Innate immune system","Immune system","Medicine","Allergic inflammation","Interleukin 13","Interleukin 22","Interleukin 33","Inflammation","Interleukin","upper airway","allergic rhinitis","Chronic Rhinosinusitis","Group 2 Innate Lymphoid Cells","Proallergic Cytokines"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:16:01.601552Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}