{"doi":"10.1016/j.ajt.2025.11.015","title":"Donor major histocompatibility complex–specific immunoglobulin E augments the T and B cell alloresponse in a CD23-dependent manner","abstract":"The emergence of immunoglobulin E (IgE) antibodies specific for donor major histocompatibility complex (MHC) has been observed in murine transplant models and kidney transplant recipients. Although IgE's significance in allergies and other TH2-type diseases is well-documented, its potential role in transplant rejection remains largely unexplored. Besides its involvement in immediate-type allergic hypersensitivity reactions via its high-affinity receptor FcϵRI, IgE augments allergen-specific T cell activation and antibody production through its low-affinity receptor FcϵRII/CD23, a process termed \"facilitated antigen presentation (FAP)\" Here, we investigate whether donor MHC-specific IgE amplifies allo-immune responses in transplantation through CD23-dependent FAP. Upon rejection of a mismatched cardiac allograft, murine recipients exhibited elevated frequencies of FcεRI+ basophils and IgE+CD23+ B cells in blood and spleen, along with increased levels of IgE binding via FcεRI and CD23. In vitro, donor-specific IgE facilitated the binding of donor MHC antigens to B cells. Employing a footpad immunization model, IgE enhanced T cell activation and proliferation and increased the levels of donor-reactive B and germinal center B cells in draining lymph nodes via a CD23-dependent process. These findings reveal that donor-specific IgE amplifies the alloresponse by promoting the activation and proliferation of donor-reactive lymphocytes through CD23-dependent mechanisms, uncovering a potential role for IgE in transplant rejection.","journal":"American Journal of Transplantation","year":2025,"id":583719,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1219555,"name":"Moritz Muckenhuber","orcid":"0000-0001-5049-2048","position":1,"is_corresponding":false},{"id":1496279,"name":"Marlena Muhm","orcid":"0009-0002-3999-6629","position":2,"is_corresponding":false},{"id":1496280,"name":"Jasmin Mucha","orcid":"0000-0001-7266-922X","position":3,"is_corresponding":false},{"id":1219558,"name":"Romy Steiner","orcid":"0000-0002-5514-7232","position":4,"is_corresponding":false},{"id":1496703,"name":"Lisa Prickler","orcid":null,"position":5,"is_corresponding":false},{"id":1219559,"name":"Verena Kainz","orcid":"0000-0002-6805-0077","position":6,"is_corresponding":false},{"id":1460624,"name":"Birgit Linhart","orcid":"0000-0001-6857-3049","position":7,"is_corresponding":false},{"id":1219561,"name":"Thomas Wekerle","orcid":"0000-0001-5159-2796","position":8,"is_corresponding":false},{"id":1219557,"name":"Anna Marianne Weijler","orcid":"0000-0002-2768-0881","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:59:07.970345Z","pmid":"41317870","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}