{"doi":"10.1016/j.ajt.2025.04.016","title":"Human type 1 conventional dendritic cells contribute to skin transplant rejection","abstract":"<h2>Abstract</h2> The skin is the most immunogenic tissue in transplantation and the most difficult tissue in which to induce immune modulation. Batf3-dependent type 1 conventional dendritic cells (cDC1s) are important in initiating rejection in murine skin transplantation. In humans, the CD141<sup>+</sup> cDC1 subset is the functional counterpart of the murine Batf3-dependent cDC1s. However, their contribution to the rejection of human skin allografts remains unknown. Using samples from human face and upper extremity transplant recipients, we demonstrated that CD141<sup>+</sup> cDC1s are increased and more activated in human skin grafts than native skin tissue from the same individual. Moreover, circulating and tissue CD141<sup>+</sup> cDC1s were elevated at rejection time points. Local modulation of graft CD141<sup>+</sup> cDC1s decreased HLA-DR expression and increased regulatory T cells, which correlated with a decreased presence of skin allogeneic T cells in a humanized transplantation model. Thus, CD141<sup>+</sup> cDC1s play an important role in rejecting human skin allografts, and their local modulation is a promising therapeutic approach.","journal":"American Journal of Transplantation","year":2025,"id":518271,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":457498,"name":"Catherine Lee","orcid":"0000-0001-8525-9342","position":1,"is_corresponding":false},{"id":892925,"name":"Kyla Mucciarone","orcid":"0000-0003-3755-2370","position":2,"is_corresponding":false},{"id":1168381,"name":"Karina Lima","orcid":"0000-0003-2478-1182","position":3,"is_corresponding":false},{"id":643467,"name":"Isadora T. Lape","orcid":null,"position":4,"is_corresponding":false},{"id":1385703,"name":"Mauricio Lima-Filho","orcid":"0000-0001-8944-3542","position":5,"is_corresponding":false},{"id":1386171,"name":"Bruno Ayoama","orcid":null,"position":6,"is_corresponding":false},{"id":282632,"name":"Branislav Kollár","orcid":"0000-0001-6668-7798","position":7,"is_corresponding":false},{"id":709919,"name":"Rodrigo Benedetti Gassen","orcid":"0000-0003-0513-1555","position":8,"is_corresponding":false},{"id":393572,"name":"Cristina Bonorino","orcid":"0000-0003-2755-3978","position":9,"is_corresponding":false},{"id":388193,"name":"Simon G. Talbot","orcid":"0000-0002-6092-7401","position":10,"is_corresponding":false},{"id":282640,"name":"Bohdan Pomahač","orcid":"0000-0003-3703-8240","position":11,"is_corresponding":false},{"id":40506,"name":"Christine G. Lian","orcid":"0000-0003-4626-1612","position":12,"is_corresponding":false},{"id":340206,"name":"George J. Murphy","orcid":"0000-0003-3464-793X","position":13,"is_corresponding":false},{"id":282635,"name":"John Y. Choi","orcid":"0000-0002-9299-3921","position":14,"is_corresponding":false},{"id":282633,"name":"Thiago J. Borges","orcid":"0000-0002-6554-0169","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:49:09.679930Z","pmid":"40286910","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}