{"doi":"10.1016/j.ajpc.2025.101018","title":"Association of life’s essential 8 score with incidence of atrial fibrillation: The Framingham heart study","abstract":"Background Atrial fibrillation (AF) burden can be reduced by targeting modifiable risk factors. Limited data exist on the association between American Heart Association’s Life’s Essential 8 (LE8) score (higher scores healthier) and AF incidence. Methods We studied AF-free Framingham Heart Study Offspring and Omni 1 participants aged ≥45 years who attended ≥1 index exam in which LE8 components were assessed. LE8 scores were calculated incorporating body mass index, blood pressure, non-HDL cholesterol, glucose, smoking, physical activity, diet, and sleep. Fine-Gray hazards models, accounting for the competing risk of death, were used to calculate subdistribution hazards ratios (sHR) for the association of LE8 score and its components with 10-year AF incidence. Results We included 3,161 unique participants (n=4,628 index exams, 57% women, mean age 65±9 years). Participants were classified as having “ideal” (LE8≥80; 16% [n=763 exam cycles]), “intermediate” (LE8 50-79; 76% [n=3,519]), or “poor”(LE8<50; 7% [n=346]) cardiovascular health. There were 410 incident AF events (10.4/1,000 person-years). Compared with “ideal”, a “poor” LE8 score was associated with higher AF risk (sHR,1.78; 95%CI, 1.20-2.64; p=0.004); we did not observe a statistically significant association comparing participants with “intermediate” LE8 scores to those with “low” LE8 scores with regards to AF risk. Higher LE8 scores (healthier; continuous) were associated with lower AF risk (sHR per 1-SD increase increment of LE8 score, 0.80; 95%CI, 0.72-0.90; p<0.0001). Conclusions Lower LE8 scores were associated with greater risk of developing AF. Future studies of the role of LE8 in reducing AF burden in the overall population are warranted.","journal":"American Journal of Preventive Cardiology","year":2025,"id":541356,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9571,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1430090,"name":"A. Daniels","orcid":null,"position":1,"is_corresponding":false},{"id":890756,"name":"Brenton Prescott","orcid":"0000-0002-3805-9070","position":2,"is_corresponding":false},{"id":337722,"name":"Vanessa Xanthakis","orcid":"0000-0002-7352-621X","position":3,"is_corresponding":false},{"id":255091,"name":"Matthew Nayor","orcid":"0000-0002-6993-9396","position":4,"is_corresponding":false},{"id":705695,"name":"Priya Gajjar","orcid":null,"position":5,"is_corresponding":false},{"id":1034,"name":"Emelia J. Benjamin","orcid":"0000-0003-4076-2336","position":6,"is_corresponding":false},{"id":599830,"name":"Sarah R. Preis","orcid":"0000-0002-9360-4166","position":7,"is_corresponding":false},{"id":1429704,"name":"Camilo Toro","orcid":"0000-0002-5620-4470","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:52:47.161928Z","pmid":"40585337","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}