{"doi":"10.1016/j.ajpc.2024.100871","title":"Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trial","abstract":"• In this ancillary study of a double-blind, randomized, response-adaptive trial that tested the effects of 4 doses of vitamin D3 supplementation, there were no significant changes in hs-cTnI and NT-proBNP over time at 3 months, 12 months, or 24 months between dose assignments. • There is an inverse association between vitamin D level and hs-cTnI. Nevertheless, higher supplementation of vitamin D3 does not improve hs-cTnI changes over time. • These findings do not support use of higher doses of vitamin D3 to prevent CVD events. In observational studies, older adults with low serum vitamin D levels are at higher risk of cardiovascular disease (CVD), but randomized trials have failed to demonstrate reduction in CVD risk from vitamin D supplementation, possibly because the doses of vitamin D supplements tested were too low. Our objective was to determine if higher doses of vitamin D supplementation reduce high-sensitivity cardiac troponin (hs-cTnI) and N-terminal pro-b-type natriuretic peptide (NT-proBNP), markers of subclinical CVD. The Study to Understand Fall Reduction and Vitamin D in You (STURDY) was a double-blind, randomized, response-adaptive trial that tested the effects of 4 doses of vitamin D3 supplementation (200, 1000, 2000, 4000 IU/day) on fall risk among older adults with low serum 25-hydroxyvitamin D concentrations (10–29 ng/mL). Hs-cTnI and NT-proBNP levels were measured at baseline, 3-, 12-, and 24-month follow-up visits. For this ancillary study, we used data from the original trial and compared participants by treatment group: low-dose (200 IU/day) or high-dose (1000+ IU/day). The effects of vitamin D dose on biomarkers were assessed via mixed effects tobit models. Among 688 participants (mean age of 76.5) hs-cTnI increased in both the low- and high-dose groups by 5.2 % and 7.0 %, respectively; likewise, NT-proBNP increased by 11.3 % and 9.3 %, respectively. Compared to the low-dose, high-dose vitamin D supplementation did not affect hs-cTnI (1.6 %-difference; 95 % CI: -5.3, 8.9) or NT-proBNP (-1.8 %-difference; 95 % CI: -9.3, 6.3). Compared to low-dose vitamin D supplementation, doses ≥1,000 IU/ day did not affect markers of subclinical CVD in older adults with low serum vitamin D levels.","journal":"American Journal of Preventive Cardiology","year":2024,"id":472005,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9465,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1126203,"name":"William Earle","orcid":"0000-0003-4934-0164","position":1,"is_corresponding":false},{"id":236349,"name":"Erin D. Michos","orcid":"0000-0002-5547-5084","position":2,"is_corresponding":false},{"id":290141,"name":"Edgar R. Miller","orcid":null,"position":3,"is_corresponding":false},{"id":409899,"name":"Amal A. Wanigatunga","orcid":"0000-0002-5763-5184","position":4,"is_corresponding":false},{"id":1040102,"name":"Heather Rebuck","orcid":"0009-0005-9743-8299","position":5,"is_corresponding":false},{"id":1307153,"name":"Robert K. Christensen","orcid":"0000-0001-6850-4975","position":6,"is_corresponding":false},{"id":264188,"name":"Jennifer A. Schrack","orcid":"0000-0001-9244-9267","position":7,"is_corresponding":false},{"id":737401,"name":"Christine Mitchell","orcid":"0000-0002-8211-281X","position":8,"is_corresponding":false},{"id":336893,"name":"Rita R. Kalyani","orcid":"0000-0002-1530-6884","position":9,"is_corresponding":false},{"id":277163,"name":"Lawrence J. Appel","orcid":"0000-0002-0673-6823","position":10,"is_corresponding":false},{"id":291339,"name":"Stephen P. Juraschek","orcid":"0000-0003-4168-2696","position":11,"is_corresponding":false},{"id":975185,"name":"Katharine Rainer","orcid":null,"position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:05:53.032464Z","pmid":"39850664","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}