{"doi":"10.1016/j.ajpc.2023.100610","title":"Association between weight variability, weight change and clinical outcomes in hypertension","abstract":"The effect of body weight variability (BWV) and body weight change (BWC) in high-risk individuals with hypertension, but without diabetes mellitus (DM) remains unclear. We examined the effect of BWV and BWC on the primary outcome [the composite of myocardial infarction (MI), other acute coronary syndromes, stroke, acute decompensated heart failure (HF), or cardiovascular (CV) death] and all-cause mortality in the Systolic Blood Pressure Intervention Trial (SPRINT). In this post-hoc analysis, we used multivariate Cox regression models to examine the risk associated with BWV and BWC for the primary outcome in SPRINT. BWV was defined as the intra-individual average successive variability (ASV). BWC was defined as baseline weight minus final weight. A total of 8714 SPRINT participants (mean age 67.8±9.4 years, 35.1% women, 58.9% Whites) who had data on weight were included. The median follow-up was about 3.9 years (IQR, 3.3-4.4). In multivariable-adjusted Cox models, each 1 unit standard deviation (SD) of BWV was significantly associated with a higher risk for the primary outcome, all-cause mortality, HF, MI, and stroke [HR(95% CI)]: 1.13 (1.07 - 1.19; p <.0001), 1.22 (1.14 - 1.30; p<.0001), 1.16 (1.07 - 1.26; p<.001), 1.10 (1.00 - 1.20; p=0.047), and 1.15 (1.05 - 1.27; p=0.005), respectively. Similarly, each 1 unit SD of BWC was significantly associated with a higher risk of the primary outcome, all-cause mortality, MI, and HF: 1.11(1.02 - 1.21; p=0.017), 1.44 (1.26 - 1.65; p<.0001), 1.16 (1.01 - 1.32; p=0.041) and 1.19 (1.02 - 1.40; p=0.031) respectively. However, there was no significant association with CV death (for both BWV and BWC) or stroke (BWC). In high-risk hypertension, BWV and BWC were both associated with higher risk of the primary outcome and all-cause mortality. These results further stress the clinical importance of sustained weight loss and minimizing fluctuations in weight in hypertension.","journal":"American Journal of Preventive Cardiology","year":2023,"id":366267,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":762447,"name":"Matthew J. Singleton","orcid":"0000-0002-7266-0951","position":1,"is_corresponding":false},{"id":1122930,"name":"Muhammad Imtiaz Ahmad","orcid":null,"position":2,"is_corresponding":false},{"id":696838,"name":"Arnaud D. Kazé","orcid":"0000-0002-5470-8296","position":3,"is_corresponding":false},{"id":430016,"name":"Parag Anilkumar Chevli","orcid":"0000-0002-4084-8175","position":4,"is_corresponding":false},{"id":1122931,"name":"Juliana H. Namutebi","orcid":null,"position":5,"is_corresponding":false},{"id":850107,"name":"Ramla N. Kasozi","orcid":"0000-0001-9621-1619","position":6,"is_corresponding":false},{"id":1122932,"name":"Denis D. Asiimwe","orcid":null,"position":7,"is_corresponding":false},{"id":1122508,"name":"Joseph Kazibwe","orcid":"0000-0002-8315-1503","position":8,"is_corresponding":false},{"id":159550,"name":"Michael D Shapiro","orcid":"0000-0002-9071-3287","position":9,"is_corresponding":false},{"id":706211,"name":"Joseph Yeboah","orcid":"0000-0001-6274-5882","position":10,"is_corresponding":false},{"id":1122507,"name":"Richard Kazibwe","orcid":"0000-0001-7085-3373","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T01:14:55.198227Z","pmid":"37942025","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}