{"doi":"10.1016/j.ajpath.2023.02.013","title":"Severe Acute Respiratory Syndrome Coronavirus 2 Vasculopathy in a Syrian Golden Hamster Model","abstract":"Clinical evidence of vascular dysfunction and hypercoagulability as well as pulmonary vascular damage and microthrombosis are frequently reported in severe cases of human coronavirus disease 2019 (COVID-19). Syrian golden hamsters recapitulate histopathologic pulmonary vascular lesions reported in patients with COVID-19. Herein, special staining techniques and transmission electron microscopy further define vascular pathologies in a Syrian golden hamster model of human COVID-19. The results show that regions of active pulmonary inflammation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are characterized by ultrastructural evidence of endothelial damage with platelet marginalization and both perivascular and subendothelial macrophage infiltration. SARS-CoV-2 antigen/RNA was not detectable within affected blood vessels. Taken together, these findings suggest that the prominent microscopic vascular lesions in SARS-CoV-2-inoculated hamsters likely occur due to endothelial damage followed by platelet and macrophage infiltration.","journal":"American Journal Of Pathology","year":2023,"id":369899,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417924,"name":"Christopher M. Weiss","orcid":"0000-0003-4704-9533","position":1,"is_corresponding":false},{"id":556146,"name":"Hongwei Liu","orcid":"0000-0003-2540-4645","position":2,"is_corresponding":false},{"id":265556,"name":"Kenneth A. Jackson","orcid":null,"position":3,"is_corresponding":false},{"id":712913,"name":"M. Kevin Keel","orcid":"0000-0002-0995-1617","position":4,"is_corresponding":false},{"id":413412,"name":"Christopher J. Miller","orcid":"0000-0002-1381-1975","position":5,"is_corresponding":false},{"id":399793,"name":"Koen K. A. Van Rompay","orcid":"0000-0002-7375-1337","position":6,"is_corresponding":false},{"id":407475,"name":"Lark L. Coffey","orcid":"0000-0002-0718-5146","position":7,"is_corresponding":false},{"id":264360,"name":"Patricia A. Pesavento","orcid":"0000-0001-6593-9607","position":8,"is_corresponding":false},{"id":407471,"name":"Erin E. Ball","orcid":"0000-0002-8464-6612","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T01:15:32.670954Z","pmid":"36906263","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}