{"doi":"10.1016/j.ajog.2003.12.006","title":"Optical detection of high-grade cervical intraepithelial neoplasia in vivo: results of a 604-patient study","abstract":null,"journal":"American Journal of Obstetrics and Gynecology","year":2004,"id":602863,"datarank":0.6782682865573562,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"self_citation_contribution":0.6782682865573562,"citation_network_contribution":0.0,"self_endowment_contribution":0.6782682865573562,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":91,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1546330,"name":"Ramon M Cestero","orcid":null,"position":1,"is_corresponding":false},{"id":1546332,"name":"Francisco A Garcia","orcid":null,"position":2,"is_corresponding":false},{"id":1546334,"name":"Michael A Gold","orcid":null,"position":3,"is_corresponding":false},{"id":1546336,"name":"Richard S Guido","orcid":null,"position":4,"is_corresponding":false},{"id":1546338,"name":"Kathleen McIntyre-Seltman","orcid":null,"position":5,"is_corresponding":false},{"id":1546339,"name":"Diane M Harper","orcid":null,"position":6,"is_corresponding":false},{"id":1546340,"name":"Louis Burke","orcid":null,"position":7,"is_corresponding":false},{"id":1546341,"name":"Stephen T Sum","orcid":null,"position":8,"is_corresponding":false},{"id":1546342,"name":"Ross F Flewelling","orcid":null,"position":9,"is_corresponding":false},{"id":1546343,"name":"Ronald D Alvarez","orcid":null,"position":10,"is_corresponding":false},{"id":1546328,"name":"Warner K Huh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Optical detection of high-grade cervical intraepithelial neoplasia in vivo: results of a 604-patient study","abstract":"<h4>Objective</h4>The purpose of this study was to assess the in vivo optical detection of high-grade cervical intraepithelial neoplasia (2/3+) on the whole cervix with a noncontact, spectroscopic device.<h4>Study design</h4>Cervical scanning devices collected intrinsic fluorescence and broadband white light spectra and video images from 604 women during routine colposcopy examinations at 6 clinical centers. A statistically significant dataset was developed of intrinsic fluorescence and white light-induced cervical tissue spectra that was correlated to expert histopathologic determination. On the basis of a retrospective analysis of the acquired data, a classification algorithm was developed, validated, and optimized.<h4>Results</h4>Intrinsic fluorescence, backscattered white light, and video imaging each contribute complementary information to diagnostic algorithms for high-grade cervical neoplasia. More than 10000 measurements that were made on colposcopically identified tissue from >500 subjects were the basis for algorithm training and testing. Algorithm performance demonstrated a sensitivity of approximately 90%. This performance was confirmed by various training methods. With the use of a multivariate classification algorithm, optical detection is predicted to detect 33% more high-grade cervical intraepithelial neoplasia (2/3+) than colposcopy alone.<h4>Conclusion</h4>Full cervix optical interrogation for the detection of high-grade cervical intraepithelial neoplasia is feasible and appears capable of detecting more high-grade cervical intraepithelial neoplasia than colposcopy alone. With the use of this classification algorithm, a multisite, randomized controlled trial is underway that compares the combination of optical detection and colposcopy versus colposcopy alone.","is_dataset_classified":null,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15167826","pmcid":null,"openalex_id":"https://openalex.org/W2097275151","authors":[],"funders":[],"total_grants":0,"fwci":6.1156,"citation_percentile":0.96849178,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":5},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0002937803021252?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0002937803021252?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ajog.2003.12.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15167826","host_type":"repository"}],"fields_of_study":["Cervical Cancer and HPV Research","Optical Imaging and Spectroscopy Techniques","Photodynamic Therapy Research Studies","Adolescent","Adult","Aged","Algorithms","Cohort Studies","Colposcopy","Female","Fiber Optic Technology","Humans","Middle Aged","Neoplasm Staging","Retrospective Studies","Sensitivity and Specificity","Spectrometry, Fluorescence","Uterine Cervical Neoplasms","Uterine Cervical Dysplasia"],"mesh_terms":["Adolescent","Adult","Aged","Algorithms","Uterine Cervical Dysplasia","Uterine Cervical Neoplasms","Colposcopy","Female","Fiber Optic Technology","Humans","Middle Aged","Neoplasm Staging","Retrospective Studies","Sensitivity and Specificity","Spectrometry, Fluorescence","Cohort Studies"],"keywords":["Colposcopy","Cervical intraepithelial neoplasia","Medicine","Cervix","Intraepithelial neoplasia","Cervical cancer","Radiology","Pathology","Internal medicine","Cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T20:30:09.841871Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}