{"doi":"10.1016/j.ajo.2016.07.019","title":"Sequential Bilateral Corneal Transplantation and Graft Survival","abstract":null,"journal":"American Journal of Ophthalmology","year":2016,"id":685851,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1791863,"name":"Elinor Curnow","orcid":null,"position":1,"is_corresponding":false},{"id":1791864,"name":"Robert Cheeseman","orcid":null,"position":2,"is_corresponding":false},{"id":704571,"name":"Vito Romano","orcid":"0000-0002-5148-7643","position":3,"is_corresponding":false},{"id":1791865,"name":"Abigail Kaye","orcid":null,"position":4,"is_corresponding":false},{"id":855835,"name":"Mark Jones","orcid":"0000-0001-9946-9463","position":5,"is_corresponding":false},{"id":1791866,"name":"Stephen Kaye","orcid":null,"position":6,"is_corresponding":false},{"id":1791862,"name":"Bernhard Steger","orcid":"0000-0002-5316-4661","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sequential Bilateral Corneal Transplantation and Graft Survival","abstract":"PURPOSE: To investigate graft survival and rejection following sequential bilateral corneal transplantation.\nDESIGN: Retrospective cohort study.\nMETHODS: The study included patients with Fuchs endothelial dystrophy (FED), pseudophakic bullous keratopathy (PBK), or keratoconus who had undergone a penetrating keratoplasty (PK), endothelial keratoplasty (EK), or deep anterior lamellar keratoplasty (DALK) between 1999 and 2012. The main cohort included patients who had received a first transplant in both eyes for the same indication and a control cohort patients who had undergone a unilateral first corneal transplant. Main outcome measures were graft rejection or failure at 5 years.\nRESULTS: A total of 11 822 patients were included, of whom 9335 had a unilateral and 2487 bilateral corneal transplantation. For patients with FED (P < .005) and KC (P = .03) but not PBK (P = .19), a transplant in the second eye was associated with a 50% reduction in risk of graft failure within 5 years in the first eye (FED: hazard ratio [HR] 0.47, 95% confidence interval [CI]: 0.34-0.64; KC: HR 0.50, 95% CI: 0.24-1.02). For FED this was dependent on the type of transplant (EK: HR 0.30, 95% CI: 0.17-0.52; PK: HR 0.61, 95% CI: 0.42-0.88). We found no association between a transplant in the second eye and a rejection episode in the first eye (KC P = .19, FED P = .39, PBK P = .19).\nCONCLUSION: For FED and KC, a transplant in the second eye was associated with a reduced risk of graft failure in the first eye, independent of inter-transplant time. For FED this effect was pronounced following an EK in the first eye, where the risk of failure was reduced by 70%.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27491697","pmcid":null,"openalex_id":"https://openalex.org/W2498974848","authors":[],"funders":[],"total_grants":0,"fwci":1.304,"citation_percentile":0.80054947,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2021,"count":3},{"year":2022,"count":7},{"year":2024,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0002939416303658?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0002939416303658?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ajo.2016.07.019","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27491697","host_type":"repository"},{"url":"https://research-information.bris.ac.uk/en/publications/b7f69779-57cf-40f4-a386-631408ab8db2","host_type":"repository"},{"url":"https://hdl.handle.net/11379/571558","host_type":"repository"}],"fields_of_study":["Corneal surgery and disorders","Corneal Surgery and Treatments","Glaucoma and retinal disorders","Adult","Aged","Cohort Studies","Corneal Diseases","Female","Graft Rejection","Graft Survival","Humans","Keratoplasty, Penetrating","Male","Middle Aged","Retrospective Studies","Risk Factors","Visual Acuity"],"mesh_terms":["Adult","Aged","Corneal Diseases","Female","Graft Rejection","Graft Survival","Humans","Male","Middle Aged","Retrospective Studies","Risk Factors","Visual Acuity","Cohort Studies","Keratoplasty, Penetrating"],"keywords":["Medicine","Keratoconus","Corneal transplantation","Hazard ratio","Corneal Transplant","Retrospective cohort study","Transplantation","Cohort","Surgery","Corneal graft","Ophthalmology","Confidence interval","Cohort study","Cornea","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T17:51:06.080142Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}