{"doi":"10.1016/j.ajic.2011.04.002","title":"A Clostridium difficile infection “intervention”: Change in toxin assay results in fewer C difficile infection cases without changes in patient outcomes","abstract":null,"journal":"American Journal of Infection Control","year":2012,"id":615725,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1587195,"name":"Kathleen M. McMullen","orcid":null,"position":1,"is_corresponding":false},{"id":1204052,"name":"Anthony J. Russo","orcid":"0000-0002-0623-6618","position":2,"is_corresponding":false},{"id":1587196,"name":"Susan M. Copper","orcid":null,"position":3,"is_corresponding":false},{"id":316348,"name":"David K. Warren","orcid":"0000-0001-8679-8241","position":4,"is_corresponding":false},{"id":396876,"name":"Erik R. Dubberke","orcid":"0000-0003-3779-2796","position":5,"is_corresponding":false},{"id":1587194,"name":"Zhuolin Han","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Clostridium difficile infection “intervention”: Change in toxin assay results in fewer C difficile infection cases without changes in patient outcomes","abstract":"<h4>Background</h4>Clostridium difficile infection (CDI) is most commonly diagnosed using toxin enzyme immunoassays (EIAs). A sudden decrease in CDI incidence was noted after a change in the EIA used at Barnes-Jewish Hospital in St Louis. The objective of this study was to determine whether the decreased CDI incidence related to the change in EIA resulted in adverse patient outcomes.<h4>Methods</h4>Electronic hospital databases were used to collect data on demographics, outcomes, and treatment of inpatients who had a C difficile toxin assay performed between January 4, 2009, and April 3, 2009 (period A, preassay change) and between May 21, 2009, and August 17, 2009 (period B, postassay change).<h4>Results</h4>Assays were positive in 240 of 1,221 patients (19.7%) during period A and in 106 of 1160 patients (9.1%) during period B (P < .01). There was no difference in mortality or discharge to hospice between the 2 periods (10.3% vs 10.1%; P = .90). Patients tested in period B were less likely to receive metronidazole or oral vancomycin (P < .01).<h4>Conclusions</h4>The new EIA resulted in fewer positive tests and reduced anti-CDI therapy. There was no difference in mortality between the 2 periods, suggesting that the decreased incidence was due to increased assay specificity, not decreased sensitivity.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21794950","pmcid":"PMC4156412","openalex_id":"https://openalex.org/W1965660380","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"K23AI065806","title":null},{"funder_name":"PHS HHS","grant_id":"5U01C1000333","title":null}],"total_grants":2,"fwci":0.6112,"citation_percentile":0.64249326,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0196655311003221?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0196655311003221?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ajic.2011.04.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21794950","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4156412","host_type":"repository"}],"fields_of_study":["Clostridium difficile and Clostridium perfringens research","Infection Control in Healthcare","Nosocomial Infections in ICU","Aged","Aged, 80 and over","Bacterial Toxins","Clinical Laboratory Techniques","Clostridioides difficile","Clostridium Infections","Cohort Studies","Female","Hospitals","Humans","Immunoenzyme Techniques","Incidence","Male","Middle Aged","Missouri","Sensitivity and Specificity","Survival Analysis","Treatment Outcome"],"mesh_terms":["Aged","Aged, 80 and over","Bacterial Toxins","Clostridium Infections","Female","Hospitals","Humans","Immunoenzyme Techniques","Male","Middle Aged","Missouri","Sensitivity and Specificity","Cohort Studies","Incidence","Survival Analysis","Clostridioides difficile","Treatment Outcome","Clinical Laboratory Techniques"],"keywords":["Medicine","Clostridium difficile","Clostridium difficile toxin A","C difficile","Toxin","Microbiology","Internal medicine","Gastroenterology","Antibiotics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T20:51:04.981677Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}