{"doi":"10.1016/j.ajg.2017.11.002","title":"Establishing ultrasound based transient elastography cutoffs for different stages of hepatic fibrosis and cirrhosis in Egyptian chronic hepatitis C patients","abstract":null,"journal":"Arab Journal of Gastroenterology","year":2017,"id":665903,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1738884,"name":"Mohamed Alboraie","orcid":null,"position":1,"is_corresponding":false},{"id":1738885,"name":"Rabab Fouad","orcid":null,"position":2,"is_corresponding":false},{"id":1324190,"name":"Noha Asem","orcid":"0000-0003-3400-0159","position":3,"is_corresponding":false},{"id":1738886,"name":"Mahmoud Abdo","orcid":null,"position":4,"is_corresponding":false},{"id":1738887,"name":"Hesham Elmakhzangy","orcid":null,"position":5,"is_corresponding":false},{"id":1738888,"name":"Mai Mehrez","orcid":null,"position":6,"is_corresponding":false},{"id":1738889,"name":"Hany Khattab","orcid":null,"position":7,"is_corresponding":false},{"id":1738890,"name":"Gamal Esmat","orcid":null,"position":8,"is_corresponding":false},{"id":1738883,"name":"Aisha Elsharkawy","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Establishing ultrasound based transient elastography cutoffs for different stages of hepatic fibrosis and cirrhosis in Egyptian chronic hepatitis C patients","abstract":"<h4>Background and study aim</h4>Transient elastography is widely used to assess fibrosis stage in chronic hepatitis C (CHC). We aimed to establish and validate different transient elastography cut-off values for significant fibrosis and cirrhosis in CHC genotype 4 patients.<h4>Patients and methods</h4>The data of 100 treatment-naive CHC patients (training set) and 652 patients (validation set) were analysed. The patients were subjected to routine pretreatment laboratory investigations, liver biopsy and histopathological staging of hepatic fibrosis according to the METAVIR scoring system. Transient elastography was performed before and in the same week as liver biopsy using FibroScan (Echosens, Paris, France). Transient elastography results were correlated to different stages of hepatic fibrosis in both the training and validation sets.<h4>Results</h4>ROC curves were constructed. In the training set, the best transient elastography cut-off values for significant hepatic fibrosis (≥F2 METAVIR), advanced hepatic fibrosis (≥F3 METAVIR) and cirrhosis (F4 METAVIR) were 7.1, 9 and 12.2 kPa, with sensitivities of 87%, 87.5% and 90.9% and specificities of 100%, 99.9% and 99.9%, respectively. The application of these cut-offs in the validation set showed sensitivities of 85.5%, 82.8% and 92% and specificities of 86%, 89.4% and 99.01% for significant hepatic fibrosis, advanced hepatic fibrosis and cirrhosis, respectively.<h4>Conclusion</h4>Transient elastography performs well for significant hepatic fibrosis, advanced hepatic fibrosis and cirrhosis, with validated cut-offs of 7.1, 9 and 12.2 kPa, respectively, in genotype 4 CHC patients.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29187317","pmcid":null,"openalex_id":"https://openalex.org/W2770458351","authors":[],"funders":[],"total_grants":0,"fwci":0.4911,"citation_percentile":0.67431875,"influential_citations":0,"citation_trend":[{"year":2020,"count":3},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1687197917301089?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1687197917301089?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ajg.2017.11.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29187317","host_type":"repository"}],"fields_of_study":["Liver Disease Diagnosis and Treatment","Liver Disease and Transplantation","Hepatitis C virus research","Adult","Egypt","Elasticity Imaging Techniques","Female","Hepatitis C, Chronic","Humans","Liver Cirrhosis","Male","Middle Aged","Predictive Value of Tests","ROC Curve","Retrospective Studies"],"mesh_terms":["Adult","Egypt","Female","Humans","Liver Cirrhosis","Male","Middle Aged","Predictive Value of Tests","Retrospective Studies","ROC Curve","Hepatitis C, Chronic","Elasticity Imaging Techniques"],"keywords":["Transient elastography","Cirrhosis","Medicine","Hepatic fibrosis","Liver biopsy","Fibrosis","Elastography","Gastroenterology","Biopsy","Internal medicine","Hepatitis C","Chronic hepatitis","Ultrasound","Radiology","Liver fibrosis","Pathology","Immunology","Chronic hepatitis C","Metavir"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T12:38:21.758689Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}