{"doi":"10.1016/j.ajcnut.2023.10.033","title":"Sustained effects of small-quantity lipid-based nutrient supplements provided during the first 1000 days on child growth at 9–11 y in a randomized controlled trial in Ghana","abstract":"BACKGROUND: There is limited research on whether nutritional supplementation in the first 1000 d affects long-term child outcomes. We previously demonstrated that pre- and postnatal small-quantity lipid-based nutrient supplements (SQ-LNS) increased birth weight and child length at 18 mo of age in Ghana. OBJECTIVES: We aimed to investigate the effect of pre- and postnatal SQ-LNS on child growth and blood pressure at 9-11 y. METHODS: In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, 1320 females ≤20 weeks of gestation were randomly assigned to receive daily: iron and folic acid (IFA) during pregnancy and placebo during 6 mo postpartum or multiple micronutrients (MMNs) during pregnancy and 6 mo postpartum, or SQ-LNS during pregnancy and 6 mo postpartum and for their children aged from 6 to 18 mo. We re-enrolled 966 children aged 9-11 y and assessed child blood pressure, height-for-age z-score (HAZ), body mass index (BMI)-for-age z-score, waist-to-height ratio, triceps skinfold, and midupper arm circumference. We compared SQ-LNS with control (IFA + MMN) groups adjusting for child's age. RESULTS: ; P-interaction = 0.007). Among females, HAZ was higher in the SQ-LNS [0.08 (1.04)] than in the control group [-0.16 (1.01)] (P = 0.010); among males, SQ-LNS [-0.16 (0.85)] and control groups [-0.16 (0.96)] did not differ (P = 0.974). Among children of females with BMI of <25, HAZ was higher in the SQ-LNS [-0.04 (1.00)] than in the control group [-0.29 (0.94)] (P = 0.004); among females with BMI of ≥25, SQ-LNS [-0.04 (0.91)] and control groups [0.07 (1.00)] did not differ (P = 0.281). CONCLUSIONS: There is a sustained impact of prenatal and postnatal SQ-LNS on linear growth among female children and children whose mothers were not overweight. This trial was registered at clinicaltrials.gov as NCT00970866 (https://clinicaltrials.gov/ct2/show/record/NCT00970866).","journal":"American Journal of Clinical Nutrition","year":2023,"id":348957,"datarank":0.3864686510765515,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.013732653608351368,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.013732653608351368,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":4,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9412,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT00970866"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":605908,"name":"Seth Adu‐Afarwuah","orcid":"0000-0002-2720-5474","position":1,"is_corresponding":false},{"id":1091716,"name":"Elizabeth L. 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Guyer","orcid":"0000-0003-1817-8766","position":5,"is_corresponding":false},{"id":1091717,"name":"Mavis Mensah","orcid":"0000-0003-2259-421X","position":6,"is_corresponding":false},{"id":1091718,"name":"Adom Manu","orcid":"0000-0002-1099-8623","position":7,"is_corresponding":false},{"id":1091719,"name":"Xiuping Tan","orcid":"0000-0003-0198-864X","position":8,"is_corresponding":false},{"id":1092176,"name":"Ebenezer Adjetey","orcid":null,"position":9,"is_corresponding":false},{"id":1091720,"name":"Benjamin Amponsah","orcid":"0000-0002-2597-4229","position":10,"is_corresponding":false},{"id":1092177,"name":"Maku E Demuyakor","orcid":null,"position":11,"is_corresponding":false},{"id":605907,"name":"Kathryn G. Dewey","orcid":"0000-0002-4185-3451","position":12,"is_corresponding":false},{"id":458391,"name":"Brietta M. 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