{"doi":"10.1016/j.ahjo.2022.100211","title":"Baseline QRS duration associates with cardiac recovery in patients with continuous-flow left ventricular assist device implantation","abstract":"In chronic heart failure (HF) patients supported with continuous-flow left ventricular assist device (CF-LVAD), we aimed to assess the clinical association of pre-LVAD QRS duration (QRSd) with post-LVAD cardiac recovery, and its correlation with pre- to post-LVAD change in left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDD). Chronic HF patients (n = 402) undergoing CF-LVAD implantation were prospectively enrolled, at one of the centers comprising the U.T.A.H. (Utah Transplant Affiliated Hospitals) consortium. After excluding patients with acute HF etiologies, hypertrophic or infiltrative cardiomyopathy, and/or inadequate post-LVAD follow up (<3 months), 315 patients were included in the study. Cardiac recovery was defined as LVEF ≥ 40 % and LVEDD < 6 cm within 12 months post-LVAD implantation. Patients fulfilling this condition were termed as responders (R) and results were compared with non-responders (NR). Thirty-five patients (11 %) achieved ‘R’ criteria, and exhibited a 15 % shorter QRSd compared to ‘NR’ (123 ± 37 ms vs 145 ± 36 ms; p < 0.001). A univariate analysis identified association of baseline QRSd with post-LVAD cardiac recovery (OR: 0.986, 95 % CI: 0.976–0.996, p < 0.001). In a multivariate logistic regression model, after adjusting for duration of HF (OR: 0.990, 95 % CI: 0.983–0.997, p = 0.006) and gender (OR: 0.388, 95 % CI: 0.160–0.943, p = 0.037), pre-LVAD QRSd exhibited a significant association with post-LVAD cardiac structural and functional improvement (OR: 0.987, 95 % CI: 0.977–0.998, p = 0.027) and the predictive model showed a c-statistic of 0.73 with p < 0.001. The correlations for baseline QRSd with pre- to post-LVAD change in LVEF and LVEDD were also investigated in ‘R’ and ‘NR’ groups. Chronic advanced HF patients with a shorter baseline QRSd exhibit an increased potential for cardiac recovery after LVAD support.","journal":"American Heart Journal Plus Cardiology Research and Practice","year":2022,"id":311412,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":726951,"name":"Christos P. Kyriakopoulos","orcid":"0000-0001-9415-1245","position":1,"is_corresponding":false},{"id":232402,"name":"Iosif Taleb","orcid":"0000-0002-0029-5019","position":2,"is_corresponding":false},{"id":864452,"name":"Elizabeth Dranow","orcid":"0000-0002-5324-192X","position":3,"is_corresponding":false},{"id":788067,"name":"Monte Scott","orcid":"0000-0002-3165-5961","position":4,"is_corresponding":false},{"id":237803,"name":"Ravi Ranjan","orcid":"0000-0002-3321-2435","position":5,"is_corresponding":false},{"id":105635,"name":"Michael T. Yin","orcid":"0000-0002-9346-9056","position":6,"is_corresponding":false},{"id":864453,"name":"Eleni Tseliou","orcid":"0000-0002-9350-2282","position":7,"is_corresponding":false},{"id":726953,"name":"Rami Alharethi","orcid":"0000-0002-2095-1431","position":8,"is_corresponding":false},{"id":726952,"name":"W. Caine","orcid":"0000-0002-2064-6904","position":9,"is_corresponding":false},{"id":344072,"name":"Robin M. Shaw","orcid":"0000-0001-7429-6092","position":10,"is_corresponding":false},{"id":408925,"name":"Craig H. Selzman","orcid":"0000-0001-9218-4764","position":11,"is_corresponding":false},{"id":232416,"name":"Stavros G. Drakos","orcid":"0000-0002-1223-327X","position":12,"is_corresponding":false},{"id":444263,"name":"Derek J. Dosdall","orcid":"0000-0001-5059-6824","position":13,"is_corresponding":false},{"id":534954,"name":"Muhammad S. Khan","orcid":"0000-0002-9449-961X","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T00:33:28.480200Z","pmid":"38558900","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}